多肽分子自组装研究进展

Progress in Study of Self-assembling Peptides

多肽分子自组装是生物体中广泛存在的一种现象。通过自组装,多肽分子可结合成具有不同功能的蛋白质分子。一种有生物功能的蛋白质分子,其特定空间结构的形成实际上就是其组成氨基酸分子中各基团组装的结果。因此,多肽分子自组装可在分子水平上进行精巧的设计,从而控制组装体的形状和结构,这在生物活性肽类药物以及生物医学材料的研制方面有着巨大的潜力。近年来,多肽分子自组装进展迅速,在模拟天然生物分子的功能、药物载体以及合成多肽药物等方面得到应用。本文仅就肽自组装系统的研究进展进行简要评述。

Self-assembly of peptides is ubiquitous in the body of creatures. The molecules of peptides combine with each other to form proteins with different functions through self-assembly. The formation of a specific conformation of one type of protein is owing to the self-assembly of its compositive amino acids. So, researchers can design self-assembly of peptides at the molecular level and can control its formation and configuration. It has the potential for application in the preparation of new medicines and biomaterials. In recent years, self-assemhling peptides have been increasingly high-lighted and used to simulate the function of natural biomolecules, to synthesize peptide-medicine, and to serve as the carriers of medicine.