服用莫达非尼对24h睡眠剥夺条件下人前庭功能的影响

Effects of Modafinil on Vestibular Function during 24 h Sleep Deprivation.

目的观察24h睡眠剥夺(SD)条件下服用莫达非尼对正常人前庭功能的影响。方法以8名健康男性青年志愿者为对象,在间隔1周的两次24h SD(从第1天8：00至第2天8：00)实验中交叉服用莫达非尼和安慰剂200mg(于第2天0：00服用),于第1天21：00及服药后1h、3h、5h、7h进行前庭功能测定。结果 SD使伪随机扫视跟踪精确度明显下降、视前庭眼动反射(visual-vestibuIar optokinetic reflex ,WOR)和视动眼震(optokinetic nystagmus,OKN)增益明显降低,特别是第2天1：00～5：00；与安慰剂组相比,莫达非尼组的OKN增益明显增加。安慰剂组和莫达非尼组的其它前庭功能指标无明显差异。结论 24h SD会影响正常人体的前庭功能,服用莫达非尼对其中的视动性眼震具有一定的改善作用。

Objective To investigate the effects of modafinil,a new wake-promoting agent, on vestibular function during 24 h sleep deprivation（SD）. Method Eight male healthy young volunteers were exposed to two 24 h periods of continuous wakefulness during the crossover experiment. In one period, 200 mg doses of modafinil were given and in the other, separated by one week, matching placebos were administered. The SD time started from 8：00 of the first day to 8： 00 of the second day. Drugs was given at 0： 00 of the second day. Vestibular function was tested at 21：00 of the first day and 1,3,5,7 h after drug administration. Result The accuracy of saccade tracking and the gains of WOR （visual-vestibular optokinetic reflex） and OKN （optokinetic nystagmus） in the placebo group decreased during 24 h SD, especially at 1 ： 00 ～ 5： 00 of the second day, while OKN gains in the modafinil group was increased significantly. There were no significant differences of other vestibular function between modafinil group and placebo group. Conclusion Twenty four SD can influence vestibular function in certain degree,but optokinetic nystagmus can be improved by modafinil.