超声造影剂微血管灌注建模及灌注参数初步研究

Modeling of Microvascular Perfusion Based on Ultrasonic Contrast Agent and Preliminary Studies of Perfusion Parameters.

目的建立基于超声造影剂(uItrasound contrast agent,UCA)的微血管灌注理论模型,研究各种不同灌注条件下系统的响应以及基于模型的灌注检测和灌注参数估计方法。方法用随机微分方程的形式描述成像平面区域内UCA微泡浓度与灌注参数之间的关系；从系统模型的角度来对所建立的模型进行分析和比对,确立系统的传输函数和冲激响应。结果给出了不同造影剂注射方式下,以及不同系统设置下UCA微泡浓度响应；在微血管仿体模型实验中,获得一种灌注条件下的灌注检测图像和两组时间一强度关系曲线。结论基于灌注模型的建立,首次实现了各种复杂条件下灌注系统的仿真,并对超声造影剂灌注检测和参数估计等难点问题进行了初步研究。

Objective To establish a theoretical model of microvascular perfusion based on ultrasound contrast agent （UCA） and to study the perfusion system response under different infusion conditions with the proposed model. Method The relationship between perfusion parameter and UCA bubble concentration in imaging plane was described by stochastic differential equation. The transfer function and impulse response of perfusion system were analyzed. The perfusion model was compared with system model. Result Simulation results of system concentration responses under different perfusion conditions were given. The results of time-intensity curves on blow mimic phantom experiment at one infusion mode were demonstrated. Conclusion With the proposed model, perfusion simulations under various complex perfusion conditions are performed for the first time. Preliminary studies of UCA based perfusion detection and perfusion parameter estimations are made.