血清孕酮、IL-8、TNF-α在先兆流产中的意义

The Significance of Serum Progesterone,IL-8 and TNF-α in Threatened Abortion

目的:探讨血清孕酮、IL-8和TNF-α在判断先兆流产预后中的价值。方法:①选择101例患者,分为先兆流产组(47例)、难免流产组(21例)和正常早孕组(33例)。均抽取静脉血检查血清孕酮、IL-8和TNF-α。②根据治疗结果将先兆流产患者分为成功组和失败组,运用受试者工作特性曲线(ROC曲线),确定用以预测治疗成功与否的血清孕酮临界值。结果:①3组患者的血清孕酮、IL-8、TNF-α水平差异有显著性(P<0.01)。②运用ROC曲线,我们推荐血清孕酮39.6 nmol/L作为预测先兆流产治疗成功与否的临界值。③IL-8和TNF-α随病情的好转而降低。结论:①血清孕酮、IL-8和TNF-α可以作为判断先兆流产预后的参考指标。②IL-8和TNF-α可能参与了先兆流产的发生发展。

To study the predicting value of serum progesterone, IL-8 and TNF-α in threatened abortion. Methods.One hundred and one patients with the first trimester pregnancy were divided into 3 groups： threatened abortion group （TA）, inevitable abortion group （IA） and normal early pregnancy group （NEP）, Serum progesterone, IL-8 and TNF-α concentrations were measured. The TA group was further divided into succeeded group and the failed group according to their clinical outcome and receiver-operator characteristic curves （ROC） was used to determine the cutoff point of progesterone for predicting therapeutic outcome of threaten abortion. Results：There was significant differences in progesterone, IL-8 and TNF-α among three groups（ P〈 0.01 ）. The cutoff point of serum progesterone for predicting the outcome of threaten abortion was 12.5ng/ml. Serum IL-8 and TNF-α levels decreased to normal range with turnover of threaten abortion. Conclusions： Serum progesterone, IL-8 and TNF-α can be used as markers in predicting the prognosis of threatened abortion. Serum IL-8 and TNF-αperhaps play a role in the initiation and development of threatened abortion.