摘要
长期以来，糖尿病血管并发症一直是导致糖尿病致死致残的主要原因。导致糖尿病血管病变的确切机制尚不十分明确。研究表明，与高糖有关的许多生物途径均能增加机体氧化应激发生，在动物模型和临床研究中，抗氧化治疗能有效改善和逆转高糖对管壁细胞的损害，恢复血管功能、控制或延缓动脉硬化的进程，提示氧化应激（oxidative stress，OST）在糖尿病血管并发症的形成发展中发挥重要作用，抗氧化剂的开发应用及临床评估将成为今后研究的重要方向之一。本文就氧化应激与糖尿病血管并发症方面的研究进展作一综述。
出处
《解剖学杂志》
CAS
CSCD
北大核心
2006年第1期121-123,共3页
Chinese Journal of Anatomy
参考文献21
-
1Lee HS,Son SM,Kim YK,et al.NAD(P) H oxidase participates in the signaling events in high glucose-induced proliferation of vascular smooth muscle cells.Life Sci,2003,72(24):2719-2730.
-
2Etoh T,Inoguchi T,Kakimoto M,et al.Increased expression of NAD (P) H OXidase subunits,NOX4 and p22phox,in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment.Diabetologia,2003,46(10):1428-1437.
-
3Ellis EA,Guberski DL,Somogyi-Mann M,et al.Increased H2O2,vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat.Free Radic Biol Med,2000,28(1):91-101.
-
4Cameron NE,Cotter MA,Archibald V,et al.Anti-oxidant and pro-oxidant effects on nerve conduction velocity,endoneurial blood flow and oxygen tension in non-diabetic and streptozotocindiabetic rats.Diabetologia,1994,37(5):449-459.
-
5Maulik N,Das DK.Redox signaling in vascular angiogenesis.Free Radic Biol Med,2002,33(8):1047-1060.
-
6SriVastava AK.High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells:a potential role in the pathogenesis of vascular dysfunction in diabetes.Int J Mol Med,2002,9(1):85-89.
-
7Watson PA,Nesterova A,Burant CF,etal.Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration.J Biol Chem,2001,276(49):46142-46150.
-
8Uemura S,Matsushita H,Li W,et al.Diabetes mellitus enhances vascular matrix metalloproteinase activity:role of oxidative stress.Circ Res,2001,88(12):1291-1298.
-
9Yoshida H,Ishikawa T,Nakamura H.Vitamin E/lipid peroxide ratio and susceptibility of LDL to oxidative modification in noninsulindependent diabetes mellitus.Arterioscler Thromb Vasc Biol,1997,17(7):1438-1446.
-
10Abiko T,Abiko A,Clermont AC,et al.Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes:role of oxidants and protein kinase-Cactivation.Diabetes,2003,52 (3):829-837.
同被引文献8
-
1茅彩萍,顾振纶.葛根素对糖尿病血管并发症大鼠血浆ET-NO、ET-ANF动态平衡的影响[J].中成药,2004,26(6):487-489. 被引量：7
-
2那娜,徐沛龙,钟进义.葡多酚对血管内皮细胞自由基损伤的影响[J].营养学报,2005,27(1):58-60. 被引量：9
-
3茅彩萍,顾振纶,许夕慧,曹莉.葛根素对糖尿病大鼠主动脉内皮形态功能的影响[J].中草药,2005,36(3):402-405. 被引量：21
-
4郭建友,霍海如,姜廷良.内皮细胞功能及其异质性研究的进展[J].中国临床药理学与治疗学,2005,10(10):1081-1085. 被引量：9
-
5肖健,李校堃,郭建红,周仲楼.姜黄素对过氧化氢诱导的血管内皮细胞损伤的双重作用[J].中国临床药理学与治疗学,2005,10(12):1376-1380. 被引量：13
-
6Jay MT, Chirico S, Siow RC. Modulation of vascular tone by low density lipoproteins: effects on L-arginine transport and nitric oxide synthesis[ J]. Exp Physiol, 1997 ; 82: 349 - 360.
-
7Dimmeler S, Haendeler J, Galle J, etal. Oxidized low-density lipoprotein induced apoptosis of human endothelial cells by activation of CPP32-like proteases, A mechanistic clue to the ' response to injury' hypothesis [J]. Circulation, 1997;95:1760 - 1763.
-
8魏晓莉,苏瑞斌.糖尿病血管病理机制[J].国外医学（药学分册）,2002,29(1):45-48. 被引量：5
-
1许锦东.高血压的非药物治疗[J].医药与保健,2001,0(8):49-49.
-
2郭超卿,王灿,苗明三.浅析氧化应激与糖尿病[J].中医学报,2009,24(6):24-26. 被引量：15
-
3孟庆华,李承红,王小江,石奕,冯琼.噻托溴铵联合孟鲁司特钠治疗慢性阻塞性肺疾病急性加重期的临床研究[J].西北国防医学杂志,2017,38(1):29-32. 被引量：14
-
4李花英,邱晓萍,刘小莺,王丽静,林益川,陈瑶,黄培基,刘礼斌.Graves病患者血清氧化及抗氧化能力指标的观察[J].中华内分泌代谢杂志,2011,27(6):495-497. 被引量：8
-
5王怡洁,刘好文.2型糖尿病并发脑卒中的危险因素及干预研究[J].脑与神经疾病杂志,2004,12(5):396-398. 被引量：7
-
6卜建宏,朱良争.2型糖尿病并发脑梗死的特点与机制研究进展[J].医学综述,2002,8(11):655-657. 被引量：24
-
7张凤英.高血压的非药物疗法[J].解放军健康,1997(4):18-18. 被引量：1
-
8边小维,褚海波,徐永波,张圣明,吴红娟.静脉高压对大隐静脉和脾静脉管壁细胞形态学的影响[J].中国血管外科杂志（电子版）,2011,3(1):29-31.
-
9王莉,王育瑛,吕凌云.超敏C-反应蛋白、D-二聚体的检测在2型糖尿病中的临床应用[J].实验与检验医学,2008,26(3):329-329. 被引量：1
-
10饶贤才.肺炎衣原体体外感染血管壁细胞的研究进展[J].国外医学（微生物学分册）,1998,21(2):38-39.
