摘要
目的:探讨2型糖尿病(DM)患者血管内皮损伤标志物的变化。方法:分别测定89例2型DM患者和76例正常对照者血浆可溶性血管内皮细胞蛋白C受体(sEPCR),血管性血友病因子(v WF)和可溶性血栓调节蛋白(sTM),并测定DM患者24h尿白蛋白排泄(UAE),根据尿UAE水平和病程分组进行比较分析。结果:2型DM患者血浆sEPCR、v WF及sTM水平高于正常对照组(P<0.05),并且与其尿UAE水平和病程呈显著正相关。结论:血浆sEPCR、v WF及sTM水平可作为观察2型DM并发血管病变以及严重程度的指标。
Objective: To investigate the variance of markers for vascular endothelial injury in type 2 diabetes.Method: 89 patients with type 2 diabetes were tested for soluble endothelial protein C receptor (sEPCR), von Willebrand factor (vWF) and soluble thrombomdulin (sTM). All the patients were divided into three groups according to the level of urinary albumin excretion (UAE) or according to duration of diasese.Results: The levels of sEPCR, vWF and sTM of patient group were higher than that of those in control group (P<0.05) and were positively correlated with UAE and duration of disease.Conclusion: Plasma sEPCR, vWF and sTM might be useful in the observation of vascular disease complications and the severity of injury in type 2 diabetic patients.
出处
《微循环学杂志》
2006年第1期57-58,61,共3页
Chinese Journal of Microcirculation
