能动性相关蛋白-1和缺氧诱导因子-1α在膀胱移行细胞癌中的表达及临床意义

Expression and clinical significance of MRP-1/CD9 and HIF-1α in bladder transitional cell carcinoma

目的探讨能动性相关蛋白-1(MRP-1/CD9)和缺氧诱导因子-1α(HIF-1α)在膀胱移行细胞癌中的表达及临床意义。方法采用免疫组化SP法观察46例膀胱癌石蜡标本中MRP-1/CD9和HIF-1α的表达情况,结合临床资料进行分析。结果膀胱癌组织中MRP-1/CD9和HIF-1α的阳性表达率分别为56.5%和43.5%。MRP-1/CD9阳性表达率在复发肿瘤中及随病理分级升高而下降(P<0.05),但与临床分期无关(P>0.05);HIF-1α的阳性表达率在复发肿瘤中及随病理分级、临床分期升高而升高(P<0.05)。MRP-1/CD9和HIF-1α的阳性表达率无显著相关性(P>0.05)。结论MRP-1/CD9和HIF-1α的表达可能是判断膀胱癌生物学行为的重要指标。

Objective To investigate the expression of MRP- 1/CD9 and HIF- 1α in bladder transitional cell carcinoma and its dinical significance. Methods The MRP - 1/CD9 and HIF - 1α expression was detected in 46 specimens by SP of immunohistochemistry. The results were analyzed in relation to the clinical data. Results The positive rate of MRP - 1/CD9 and HIF- 1α in bladder carcinoma was 56.5 % and 43.5 %, respectively. The MRP - 1/CD9 expression was negatively related to the tumor grade （ P 〈 0.05）, but not to tumor clinical stage （ P 〉0.05）. The positive expression rate of HIF - 1α was positively correlated with tumor grade and clinical stage （ P 〈 0.05） in recurrent tumor. There was no correlation between the positive expression rate of MRP - 1/CD9 and HIF - 1α（ P 〉 0.05）.Conclusion MRP- 1/CD9 and HIF- 1α expression may be important prognostic indicators for assessing the biological behavior of bladder transitional call carcinoma.