中药“红藤方”对子宫内膜异位症模型大鼠异位内膜的形态学影响

The Drug Effects of Traditional Chinese Medicine "Sargentgloryyme Formula" on Experimental Endometriosis in the Rat

目的:探讨清热活血中药红藤方治疗子宫内膜异位症模型大鼠异位内膜的作用。方法:采 用手术方法建立子宫内膜异位症模型大鼠。将模型大鼠83只,随机分为6组:空白对照组,去势 组,达那唑组80 mg／kg,红藤方高剂量组110 g生药／kg,中剂量组77．5 g／kg和低剂量组55g/kg。 灌胃给药3周后,剖腹测量异位子宫内膜体积,并取材作组织切片,以半自动图象分析仪对异位 内膜形态进行定量分析。结果:用药后,低剂量组与对照组异位内膜体积抑制率比较无显著性差 异(P>0．05)外,其它各组均显著低于对照组(P<0．05)。其中,高剂量组与达那唑组相比也显著 降低(P<0．05)。同时,除低剂量外,其余各组异位内膜上皮高度均显著低于对照组(P<0．01)。 结论:中药红藤方能抑制异位子宫内膜的生长。

Objective： To study the drug effects of Traditional Chinese Medicine ＂Sargentgloryyine Formula＂ on experimental cndometriosis in the rat. Method： The model of endometriosis rats was induced by transplanting with endometrium surgically. The rats were divided into 6 groups by random： the non-treatment group, the castrate group, the treatment group by Danazol （80 mg/kg）, the treatment group by high dose of Traditional Chinese Medicine ＂Sargentgloryyine Formula＂ （110 g/kg）, the medium dose group （77.5 g/kg） and the low dose group （55 g/kg）. After 3 weeks＇ treat, the volum of endometrium was detected by cutting the rats＇ belly open, the materials were drawn from endometrium for tissue section, and the quantity analysis of endometrium was done by semi-automatic image analysis machine. Results： There was no significant difference of the endometrium volum between the low dose group and the non-treatment group （P〉0.05）, all else groups＇ endometrium volums were significantly lower than those of the non-treatment group （P〈0.05）. And apart from the low dose group, all else groups＇ heights of the endometrium epithelia were significantly lower than those of the non-treatment group （P〈0.01）. Conelusion： Traditional Chinese Medicine ＂Sargentgloryyine Formula＂ can refrain the growth of the endometrium.