异黄酮类化合物的微波合成及其生物活性研究

Synthesis of isoflavones under microwave irradiation and preliminary studies on their bioactivities

以间苯二酚和取代苯乙酸为原料，在三氟化硼／乙醚催化作用下，应用微波技术合成了4种异黄酮类化合物，该反应在2～6min内完成，产率在60％-72％．在此基础上，采用家兔颅盖骨骨髓成骨细胞，就其对该成骨细胞增殖活性的影响进行了初步试验．研究表明：本文所合成的4种化合物对成骨细胞均有不同程度的促进作用．

Four isoflavones were synthesized by using one-pot procedure from the unprotected resorcinol and p-substituted phenyl acetic acid catalyzed by boron-etherate under microwave irradition within 2 - 6 min with yields of 60% - 70% respectively. Preliminary pharmacological tests of the effects on rabbit osteoblasts in vitro showed that all of these compounds could promote the proliferation of osteoblasts to a certain degree.