二硫化碳慢性接触对儿茶酚胺类代谢的影响

Effectofchronicexposuretocarbondisulphideoncatecholaminemetabolisminworkers

采用综合累积暴露指数（ＩＣＥ），将工人接触ＣＳ２浓度和接触期限结合起来定量评价暴露强度，并检测尿中２－硫代噻唑烷－４－羧酸（ＴＴＣＡ）和儿茶酚胺类神经递质代谢产物的含量。结果显示：接触组尿中ＴＴＣＡ增高，存在剂量－效应关系；高接触组高香草酸（ＨＶＡ）和香草扁桃酸（ＶＭＡ）排泄减少。这两种儿茶酚胺代谢产物与ＣＳ２浓度及工龄虽未显示有显著意义的相关，但与ＩＣＥ及ＴＴＣＡ之间却呈现统计学上的相关关系，表明长期接触ＣＳ２对儿茶酚胺类神经递质代谢有一定的干扰作用。

ThepresentstudywasundertakentoexaminetherelationshipsamongCS2exposure,urinary2-thiothiazolidine-4-carboxylicacidandtwomajormetabolitesofcatecholamine,homovanilicacid(HVA)andvanilylmandelicacid(VMA),inagroupofworkerschronicalyexposedtodiferentconcentrationofCS2inalargeviscoserayonplant.Inordertohaveabeterjudgementoncumulativeexposureintensity,theindexofcumulativeexposure(ICE)whichwastheproductofexposuredosagemultipliedbydurationofexposureyear.TheresultsshowedthatthegeometricmeanconcentrationsofCS2intheplantrangedfrom8.47to63.80mg/m3,andabout50%ofthestudiedpopulationhadbeenrepeatedlyexposedtoCS2ofaconcentrationexceededthehygienicstandardofChina(10mg/m3).UrinaryTTCAwasincreasedinthoseexposedworkerswithdose-responserelationship.Therewasasignificantlylow-erlevelofHVAandVMAintheCS2workersofhighexposedgroup.AlthoughtherewerenostatisticalcorelationsamongtwocatecholaminemetabolitesandthemeanCS2concentration,andyearsofemployment,significantdose-efectrelationshipswereobservedamongthesetwometabolitesandICEandTTCA.Theresultssuggestedthatlong-termexposuretoCS2mayinterferewithcatecholamineneurotransmitermetabolism.