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白介素-24与肺癌

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摘要 白介素-24(IL-24)即是黑色素瘤分化相关基因-7(mda-7),属于IL-10家族成员,除具免疫刺激应答功能外,还被认为是一抑癌基因。IL-24可以抑制多种肺癌细胞的生长,其主要机制是提高肿瘤抑制基因表达,减少原癌基因的表达,促进凋亡,以及抑制肿瘤血管生成。IL-24还具有增加肺癌细胞对射线敏感性的作用。IL-24有望成为肿瘤临床综合治疗的有效手段之一。
作者 朱晔涵 杨吉成 胡华成
机构地区 苏州大学附属第一医院呼吸科 苏州大学医学院基础医学系细胞和分子生物学教研室 苏州大学附属第二医院呼吸科
出处 《国际呼吸杂志》 2006年第2期109-111,共3页 International Journal of Respiration
关键词 白介素-24 黑色素瘤分化相关基因-7 肺癌
分类号 R734.2 [医药卫生—肿瘤] R562.25 [医药卫生—呼吸系统]
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参考文献16

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二级参考文献10

  • 1Fickenscher H,Hor S,Kupers H et al.The interleukin-10 family of cytokines [J].Trends Immunol,2002;23(2):89-96.
  • 2Jiang H,Lin J J,Su Z Z et al.Substraction hybridization identifies a novel melanoma-differentiation-accociated gene,mda-7,modulated during human melanoma differentiation,growth and progression [J].Oncogene,1995;11(12):2477-2486.
  • 3Lebedeva I V,Su Z Z,Chang Y et al.The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells [J].Oncogene,2002;21(5):708-718.
  • 4Caudill E G,Mumm J B,Poindexter N et al.The protein product of the tumor suppressor gene,melanoma differentiation-associated gene 7,exhibits immunostimulatory activity and is designated IL-24 [J].J Immunol,2002;168(12):6041-6046.
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  • 10Su Z,Lebedeva I V,Gopalkrishnan R V et al.A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells [J].ProcNtl Acad Sci USA,2001;98(18):10332-10337.

共引文献11

国际呼吸杂志
2006年 第2期

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