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肺移植后缺血再灌注损伤发病机制的研究进展 被引量:6

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摘要 本文综述了肺移植后缺血再灌注损伤(IRI)发病机制的研究进展,包括:①白细胞活化;②转录因子激活;③细胞膜分子的上调;④促炎症反应介质的释放;⑤蛋白酶的释放;⑥IRI的保护性物质。肺移植IRI中表现为多基因改变导致的疾病,对肺移植IRI进行基因治疗的策略,靶标应选择具有调控其它致病基因功能的关键基因。
出处 《国际呼吸杂志》 2006年第2期129-133,共5页 International Journal of Respiration
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