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缺氧诱导因子-1α在胶质瘤中的研究进展 被引量：2

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摘要 缺氧诱导因子1(Hypoxiainduciblefactor1,HIF1)是调节细胞缺氧反应的主要转录因子,HIF1α为其活性调节亚单位。HIF1α在胶质瘤中表达显著增加,并与胶质瘤的恶性进展密切相关。HIF1为异二聚体结构,调控多种与细胞缺氧反应相关基因的表达;氧水平、相关癌基因与抑癌基因及细胞因子等均可调节HIF1α蛋白的表达;HIF1α和肿瘤内新生血管形成、细胞代谢、细胞凋亡及细胞坏死之间均存在密切关系,并可影响放化疗对肿瘤的疗效;以HIF1α为靶点的药物或基因治疗正在成为胶质瘤基础和临床研究关注的热点。
作者 王国开 杨学军
机构地区 天津医科大学总医院神经外科
出处 《国际神经病学神经外科学杂志》 2006年第1期47-51,共5页 Journal of International Neurology and Neurosurgery
关键词 缺氧诱导因子-1 胶质瘤 治疗
分类号 R739.41 [医药卫生—肿瘤]
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参考文献20

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同被引文献26

  • 1杜谋选,袁军.影响人脑胶质瘤的预后因素[J].中华神经医学杂志,2005,4(2):145-148. 被引量：15
  • 2田永刚,许军,代文杰.缺氧诱导因子在肿瘤生长中的作用[J].国外医学（外科学分册）,2005,32(2):133-136. 被引量：5
  • 3Apaydin I, Konac E, Onen HI, et al. Single nucleotide polymorphisms in the hypoxia-indueible factor-lalpha (HlF-lalpha) gene in human Sporadic breast cancer[J], Arch Med Res,2008,39(3):338.
  • 4Lee S, Garner EI, Welch WR, et al. Over-expression of hypoxia - inducible factor 1 .alpha in ovarian clear cell carcinoma[J]. Gynecol Oncol, 2007,106(2) :311.
  • 5Horiuchi A, Imai T, Shiznizu M, et al. Hypoxia induced changes in the expression of VEGF, H2F-1 alpha and cell related molecules in ovarian caneer cells [ J ]. Anticancer Res, 2002,22 (5) : 2697.
  • 6Shimogai R, Kigawa J, ltamochi H, et al. Expression of hypoxia-inducible factor lalpha gene affects the outcome in patients with ovarian cancer[J]. Int J Gynecol Cancer,2008,18(3) :499.
  • 7Finlay JL, Zachatoulis S. The treatment of high grade gliomas and diffuse intrinstic pontine tumors of childhood and adolescence : a historical-and futuristic-perspective. Neurooncol, 2005,75(3) : 256-266.
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  • 10Chamberlain MC, Kormanik PA. Practical guidelines for the treatment of malignant gliomas. West J Med. 1998 , 168 (2) :114-120.

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国际神经病学神经外科学杂志
2006年 第1期

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