镁剂辅佐治疗急性高血压性脑出血的疗效观察

Effect of magnesium in patients with acute hypertensive intracerebral haemorrhage

目的探讨镁离子制剂在高血压性脑出血急性期治疗的效果。方法选择高血压幕上性出血、出血量<50ml的血患者96例,采用如何随机分组,治疗组在综合常规治疗基础上应用25%硫酸镁针20ml,对照组给予一般综合常规治疗。对比两组治疗前后的神经功能缺损程度(NDS)评分及死亡人数。结果治疗组NDS评分在用药后第7、15天NDS评分也明显优于对照组(P<0.01),而死亡人数治疗组4例(8.33%),对照组5例(10.42%),两组死亡率比较,差异无统计学意义(P>0.05)。结论早期及时补充镁离子能促进急性高血压性脑出血中小量出血患者急性期神经功能恢复,而对死亡率降低则不明显。

Objective To investigate the effect of magnesium in patients with acute hypertentive intracerebral haemorrhage. Method 96 patients with acute hypertentive intracerebral haemorrhagc with bleeding less than 50ml were divided into 2 groups. Study group was treated with 25% bitter salt and routine treatment; control group was treated with routine treatment. The NDS before and after treatment and mortality were contrasted between two groups. Result The NDS of study group was better than those of control group significantly on day 7, 15 after treatment. There were 4 death cases （8.33%） in study group and 5（10.42%） in control group, there were no significant difference between two groups. Conclusion It is of benefit to resume the acute nervice function that the patients with acute mild and moderate hypertentive intracerebral haemorrhage were treated with magnesium early , but it will not change mortality.