急性白血病患者血清、脑脊液IL-6水平及临床意义

Clinical Significance of Alterations in the Serum and CSF Levels of IL-6 in Patients with Acute Leukemia

目的:探讨IL-6在急性白血病患者血清及脑脊液中的变化、病情及预后的关系。方法:用放射免疫分析检测了急性白血病患者(38例)和正常健康人(30例)血清和脑脊液IL-6水平,对治疗前后、病情变化进行了比较。结果:1.急性白血病患者治疗前血清和脑脊液IL-6水平都明显高于正常组(P<0.01),治疗缓解后比治疗前明显降低(P<0.01);2.急性白血病患者复发或发生脑膜白血病后血清和脑脊液IL-6水平升至更高;3.急性白血病IL-6水平与白血病细胞负荷有着较好的正相关性;4.脑脊液中IL-6浓度明显升高是诊断脑膜白血病的早期敏感指标。结论:检测急性白血病患者血清和脑脊液IL-6水平,有助于了解患者的病情变化及其预后。

Objective To study the clinical significance of alterations in the serum and cerebrospinal fluid （CSF） levels of IL - 6 in patients with acute leukemia （AL）. Methods Serum and CSF IL - 6 levels were measured with radioimmunoassay in 38 patients with AL before and after treatment and in several patients during relapse after treatment as well as in 30 controls. ReSUltS （ 1 ） The serum and CSF levels of IL -6 in patients with AL before treatment were significantly higher than those in controls （P 〈0.0l ）. Of the same group patients the serum and CSF levels of IL - 6 after treatment were significantly lower than those before treatment （ P 〈 0.01 ）. （2） Levels of IL -6 in serum and CSF in patients during relapse or with CNS involvement （CNSL） were even higher than those before treatment. （3） Serum levels of IL -6 in patients with AL were well correlated with the magnitude of tumor burden. （4） CSF IL -6 is an early and sensitive indicator in detecting CNSL with AL. Conclusion Dynamic changes in serum and CSF IL - 6 levels can be utilized as an indicator of therapeutic effect as well as prognosis.