铜陵厂矿地区HP感染情况及与胃肠道疾病关系的探讨

The Endemiology of Helicobacter Pylorus Infection and Gastro-Intestinal Disease in Mine and Related Factory Workers of Tong-Ling City, Anwhei

目的:了解铜陵厂矿地区幽门螺杆菌(HP)感染情况及其与消化道疾病的关系。方法:对铜陵厂矿地区18岁以上共1076人进行分层、整群、随机抽样,进行微量胶囊14C尿素呼气试验、血清学技术和产细胞毒素幽门螺杆菌抗体试验(CagA-HP)检查,再抽取一部分阳性病人进行胃镜检查。结果:14C尿素呼气试验、血清学检查阳性721人,占67.0%,其中48.5%CagA-HP阳性。对HP影响因子由大到小依次为工作环境、消化道症状、既往史、职业、年龄、接触史、性别和不良生活习惯。结论:铜陵厂矿地区HP感染率稍高于我国普通人群,CagA阳性菌稍低于我国普通人群中感染率;HP感染大多与不良工作环境和生活习惯有关。

Objective To investigate the endemiology of H. pylorus infection and related gastro - intestinal disease in mine and factory workers of Tong - Ling area. Methods 14^C - urea breath test, serum IgG and cytotoxin - producing H. pylorus antibodies determinations were performed in 1076 randomly selected adults among the mine and related factory workers in Tong - Ling area. Gastroscopy was done in 156 subjects （cytotoxin- producing H. pylorus antibody CagA -HP positive 108 and Cag -HP negative 48）. Fiesuits Seven hundred and twenty-one subjects of the 1076 （67.0%） examined were positive with the 14C - urea breath and serological tests, among which 350 （48.5% of the 721 ） were Cag - HP positive. Factors affecting positiveness of HP infection were in the orden of： working environment, gastro -intestinal symptoms, past history, vocation, age, history of previous contact, sex and non -hygienic life - style. Conclusion The HP infection rate in Tong - Ling area was slightly higher that nationwide but with a lower CagA HP positive rate. HP infection was mostly related to the working environment and life-style.