有机磷农药中毒中心肌酶谱及肌钙蛋白I的变化

The change of myocardium enzymogram and cardiac specific troponin I in AOPP patients serum

目的通过检测有机磷中毒患者的心肌酶谱及肌钙蛋白I的水平来评价有机磷农药对心肌的损害。方法检测50例不同有机磷中毒患者中心肌酶谱,包括肌酸激酶总值(CK)、肌酸激酶同工酶(CK-MB)和乳酸脱氢酶(LDH)及肌钙蛋白I(cTnI),应用同样方法检测健康体检者30例作为对照组。结果中毒组的心肌酶谱均较对照组显著升高(P<0.01),在重度中毒组中cTnI>0.1μg.L-1,其心电图ST-T变化及死亡率也显著高于其他组(P<0.01)。结论心肌酶谱及肌钙蛋白I检测可以反映有机磷农药中毒患者的心肌损害,尤以肌钙蛋白I为佳。

Aim To evaluate the myocardium damage caused by acute organophosphorus pesticide poisoning（AopP） by determining enzymogram and cardiac specific troponin I （cTnI） of myocardium. Methods Fifty hospitalized patients had their vein blood drawn for determining enzymogram of myocardium that included CK, CK-MB, LDH and cTnI. The blood of thirty patients without cardiac disease were drawn as control. Results The patients with AOPP had higher enzymogram of myocardium than those of control group. In severe AOPP cases , the cTnI 〉 0.1μg · L^-1 ,the changes of ST-T and the morality were higher than those in control group. Conclusion The damage of AOPP to myocardium could be estimated by enzymogram and cTnIof myocardium. The latter was more useful.