鼻咽癌多药耐药相关蛋白表达与颈淋巴结放疗敏感性的研究

Relationship between the expression of MRP and the radiosensitivity of neck lymph node of NPC

目的分析多药耐药相关蛋白（multidrug resistance—associated protein，MRP）与鼻咽癌颈淋巴结放疗敏感性的关系。方法回顾性地分析我科1999年1月1日-2000年12月31日治疗的鼻咽癌，共45例。采用免疫组化S—P法，检测鼻咽癌组织中的MRP表达，并评价与颈淋巴结的放疗敏感性关系。结果鼻咽癌组织中MRP的阳性表达率为68．63％（35／51）。MRP呈阳性表达者颈淋巴结残存率（复查CT为10．00％，临床扪诊为23．33％）低于阴性表达者（复查CT为40．00％，临床扪诊为53．33％），两者差异有显著性意义（x^2=3．906和x^2=4．050，P〈0．05）。结论鼻咽癌组织中MRP有较高水平的表达。MRP在鼻咽癌组织中的表达与颈淋巴结放疗敏感性有一定的关系，作为放疗敏感性的预测指标可能有一定的临床应用意义。

Objective To study the relationship between the expression of multidrug resistance - associated protein （MRP） in nasopharyngeal carcinoma （NPC） and the radiosensitivity of neck lymph node of NPC. Methods To analyze retrospectively cases of NPC treated by radiotherapy from January, 1, 1999 to december, 31, 2000 in our department, total 45 cases. Using S - P method to detect the expression of MRP in NPC, and analyze the relationship with radiosensitivity of neck lymph node of NPC. Results The rate of positive expression was 68.63%（35/51） in NPC. The residual rate of the lymph node of MRP positive expression was lower than that of MRP negative expression （reexamination CT 10.00% and 40.00%, clinical check 23.33% and 53.33 % ）, there were significant differences （x^2 = 3.906, x^2 = 4.050, respectively, P 〈 0.05）. Condusion There is higher expression of MRP in NPC. About predicting the radiosensitivity of neck lymph node of NPC, the expression of MRP has some clinical significance.