血浆神经肽Y、神经降压素水平变化与急性心肌梗死的相关性研究

Study of relationship between changes in plasma neuropeptide Y,neurotensin levels and the acute myocardial infarction

目的研究急性心肌梗死(AMI)患者发病不同阶段血浆神经肽Y(NPY)、神经降压素(NT)水平的变化,探讨其在AMI的发生发展中的意义。方法采用放射免疫方法(RIA)测定53例AMI患者发病后第1、2、3、7、14天血浆NPY、NT的浓度变化,并选择40例健康者作对照组。结果AMI患者发病后第1、2、3天血浆NPY[(268±34)pg/ml(、217±37)pg/ml(、196±48)pg/ml]、NT[(163±27)pg/ml(、125±23)pg/ml(、71±24)pg/ml]明显高于对照组[NPY(115±27)pg/ml,NT(66±13)pg/ml](P<0.01),合并有泵功能衰竭的患者血浆NPY、NT水平明显高于泵功能正常患者[NPY(326±28)pg/ml vs(215±34)pg/ml,NT(195±32)pg/ml vs(106±37)pg/ml](P<0.01)。结论NPY、NT与AMI的病理生理过程有关,可能在AMI发生发展中发挥作用。

Ohhjeetive To study the changes in plasma neuropeptide Y（NPY） neurotensin（NT） levels in patients with acute myocardial infarction（AMI）, and to investigate the significance of theirs changes in AMI. Methods Fifty-three patients with AMI, forty normal controls were studied. Plasma NPY and NT were measured by radioimmuoaussay（RIA） in patients with AMI after admission, lday, 2 day, 3 day, 7 day, 14 day. Results The plasma NPY and NT levels in patients after AMI 1 day, 2 day, 3 day were[ （268 ± 34）pg/ml; （ 163 ± 27）pg/ml], [ （217 ± 37） pg/ml; （ 125 ± 23） pg/ml ], [ （ 196 ± 48 ） pg/ml; （ 71 ± 24） pg/ml ] ; and they were singnifeantly higher than those in normal controls [ NPY （ 115 ± 27） pg/ml, NT（66 ± 13）pg/ml ]. what＇s more, the levels of plasma NPY and NT in patients with heart failure were significantly higher than the patients with non＇hal cardiac function [ NPY （326 ± 28） pg/ml vs （ 215 ± 34 ） pg/ml, NT（ 195 ± 32 ） pg/ml vs （ 106 ± 37 ） pg/ml ] （ P 〈 0.01 ）. Conclusion NPY, NT are associated with the pathophysieal progression and might play an role in the development of AMI.