细胞周期调控与肿瘤

Cell Cycle Control and Tumor

Cyclin、CDK、CKI是细胞周期调控的内源性分子,三者在细胞周期中相互协调并与细胞信号转导通路之间形成复杂的调控网络,与细胞增殖、细胞分化及细胞凋亡相关联。现发现肿瘤中存在相应基因的突变和表达失调,这些改变直接、间接导致细胞周期紊乱,与肿瘤发生密切相关,是分子遗传学和肿瘤生物学研究的热点。

Cyclins, cyclin-dependent kin,kinases（CDKs） and cyclin-dependent kinase inhibitors（CKls） play important roles in cotrolling cell proliferation, differentiation and apoposis. Cellular CDKs activity is tightly regulated by positive and negative factors, such as cyclins, CKIs. Defects in cell cycle regulation are common causes of the abnormal proliferation of cancer cells. These fundamental studies may result in broad applications within many different fields and may, in the long term , open a new path for cancer therapy.