微卫星不稳定性与恶性肿瘤

Microsatellite Instability and Malignant Tumor

众多学者认为,遗传物质的微卫星不稳定性可导致肿瘤的发生,尤其在恶性肿瘤的发生中有特殊作用。本文对恶性肿瘤的微卫星不稳定性作一综述。

There is still much debate on the distinct classes of genomic instability and their specific roles in the initiation of tumor formation, as well as in the progressive transition to a cancerous state. The essay is an overview of the relation between microsatellite instability and malignant tumor.