多烯康对冠心病患者血管内皮功能的影响

Influence of Duoxikang on the vascular endothelial function in patients with coronary heart disease

目的研究多烯康对冠心病患者血管内皮功能的影响。方法对36例冠心病患者和30例健康人采用高分辨血管外超声技术测定肱动脉血流介导的舒张功能及硝酸甘油介导的舒张功能,冠心病组服用多烯康12周后检测。结果研究表明冠心病组肱动脉血流介导的舒张及硝酸甘油介导的舒张反应均低于对照组(P<0.01),冠心病组多烯康治疗后较前明显改善(P<0.01)。结论多烯康可改善冠心病患者血管内皮功能。

Objective To evaluate the effect of Duoxikang on vascular endothelial dilation function in patients with coronary heart disease. Methods Thirty-six patients with coronary heart disease and thirty normal subjects were studied, the flow-mediated dilatation and glyceryl trinitrate（GTN）-induced vasodilation of brachial artery were measured by high resolution ultrasound technique. After twelve weeks treatment with Duoxikang, subjects in group of coronary heart disease were remeasured. Results The flow-mediated dilatation and GTN-induced vasodilation of brachial artery in patients with coronary heart disease were significantly reduced as compared with those in control group. These indices in patients with coronary heart disease after treatment with Duoxikang were significantly better than those before the treatment. Conclusion Duoxikang may improve the vascular endothelial dilation function in patients with coronary heart disease.