摘要
Wnts家族是重要的细胞信号分子,在细胞的增值、分化及肿瘤的发生中发挥重要作用。Wnt配体通过与细胞膜上的两种受体分子相互作用发动信号传导。Wnt受体包括Frizzled受体家族和LDL相关蛋白家族。Wnt的拮抗剂分为两类,sFRP类和DKK类。sFRP类的成员包括sFRP、Wif-1和Cerberus,他们直接与Wnt配体结合,从而改变了他们与Wnt复合体结合的能力;DKK类只结合Wnt受体复合体的一个亚基。sFRPs和DKKs均能激活规则途径。在某些情况下,一种拮抗剂能抑制另一种拮抗剂的作用。研究揭示Wnt的异常激活与多种肿瘤的发生或转移有关,因此深入研究Wnt信号通路,设计出阻断Wnt通路的物质,可为将来癌症的治疗提供一种可行性的途径。
Secreted Wnt glycoproteins are one of the major families of cell signaling molecules and have a dual role in embryogenesis and carcinogenesis. Wnt proteins signals act through canonical pathway and non-canonical pathway. Wnt ligands bind to two distinct families of cell-surface receptors： the Frizzled （Fz） receptor family and the LDL-receptor related protein （LRP） family. Wnt-mediated signals are modulated extracellularly by Wnt antagonists. Wnt antagonists are asecreted proteins that bind to Wnt proteins and inhibit their activities. They can be divided into two groups： one is sFRP family, WIF-1 and Cerberus, another is DKK family. Wnt signaling has clearly emerged as a critical pathway in carcinogenesis. It deserves further study on the components of the Wnt pathway to provide valuable targets for potential anti-cancer therapeutic agents.
出处
《中国比较医学杂志》
CAS
2006年第1期58-61,共4页
Chinese Journal of Comparative Medicine
关键词
WNT
拮抗剂
信号传导
肿瘤发生
Wnt
Antagonist
Signal transduction
Carcinogenesis
