豚鼠溴敌隆急性中毒的病理形态学观察

Pathomorphological Observation of Acute Bromadiolone Poisoning in Guinea Pigs

目的观察豚鼠食入溴敌隆急性中毒的病理形态学特点。方法对中毒豚鼠进行病原微生物的分离鉴定、尸体剖检、组织病理学检查及豚鼠体内毒物分析鉴定。结果豚鼠心血、肝、肠系膜淋巴结、小肠和盲肠内容物未见致病菌生长。尸体剖检及组织病理学所见完全相同,病变特点为全身各组织器官广泛高度淤血;肺、心肌斑点状出血;胃肠道斑点状及弥漫性出血,急性出血性卡他性胃肠炎;心、肝、肾和肾上腺等实质器官变性;弥漫性肺气肿。豚鼠体内毒物分析鉴定均检出溴敌隆杀鼠剂。结论豚鼠食入溴敌隆中毒病理改变符合抗凝血类化学毒物中毒病理学特点,为快速诊治该病提供理论依据。

Objective To observe the pathomorphological characteristics of acute bromadiolone poisoning in guinea pigs. Methods Isolate and identify pathogenic bacterial strain from the intoxicated guinea pigs, and dissect the animals for histopathological examination and toxicological analysis. Results No growth of pathogenic bacterial strain was observed in the blood in the heart, liver, mesenteric lymph nodes or small intestinal and cecal contents of the guinea pigs. The result of autopsy was well consistent with that of histopathological examination, The pathomorphological changes were revealed as extensive and extreme congestion in systemic tissues and organs, flecked bleeding in lung and heart muscle, flecked and diffuse bleeding in gastrointestinal tract, acute hemorrhagic and catarrhal gastrocnteritis, degeneration of parenchymatous organs such as heart, liver, kidney and adrenal, and diffuse pulmonary emphysema, Bromadiulone was detected in the intoxicated guinea pigs. Conclusion The pathological changes of guinea pigs, which were orally administered with bromadiolone, are characteristic of anticoagulant poisoning, The study provided a reliable basis for rapid diagnosis and treatment of bromadiolone poisoning.