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CDK4在膀胱移行细胞癌中的表达及其临床意义 被引量：2

Expression of CDK4 in human bladder transitional cell carcinoma and its clinical significance
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摘要 目的:探讨CDK4蛋白在膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法:采用免疫组化方法,测定10例正常膀胱黏膜及40例BTCC标本中的CDK4蛋白的表达。结果:CDK4蛋白在正常膀胱黏膜和BTCC中的阳性表达率分别为0.00%、52.50%(P<0.05)。CDK4蛋白在G1、G2、G3中的阳性表达率依次为36.84%、61.54%、75.00%,差异无显著性(P>0.05);在Tis～T1中CDK4阳性表达率为40.00%,明显低于T2～T4中的73.33%(P<0.05)。结论:CDK4的过度表达可能在BTCC的进展中发挥了重要作用,CDK4可成为一种新的预后判断的参考指标。 Objective To investigate the expression and clinical significance of CDK4 protein in bladder transitional cell carcinoma （ BTCC ）. Methods CDK4 protein expression of 40 BTCC and 10 normal bladder tissues were analysed by immunohistochemistry. Results The positive rates of CDK4 were 52. 50% in BTCC and 0.00% in normal bladder tissues （ P〈0.05）. The positive rates of CDK4 in G1, G2 and G3 were 36. 84%, 61.54%, 75.00%, respectively; and no statistically significant difference among the three groups（ P 〉 0.05） . The positive rate of CDK4 in Tis-T1 was significantly lower than that in T2-T4（P〈0.05）. Conclusion CDK4 protein overexpression may play an important role in the development of BTCC. CDK4 may be a novel prognostic factor in BTCC.
作者 陈晓波 谭建明 陈坚
机构地区 上海交通大学附属第一人民医院肾移植科 广西医科大学第一附属医院泌尿外科
出处 《实用医学杂志》 CAS 2006年第4期380-381,共2页 The Journal of Practical Medicine
关键词 癌 移行细胞 膀胱肿瘤 免疫组织化学 细胞周期蛋白质依赖激酶类 CDK4蛋白 Carcinoma, transitional cell Bladder neoplasms Immunohistochemistry Cyclin-dependent kinases CDK4 protein
分类号 R737.14 [医药卫生—肿瘤]
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参考文献8

  • 1NURSE P. A long twentieth century of the cell cycle and beyond [J].Cell ,2000,100( 1 ): 71 - 78.
  • 2PILOTTI S, DELLA TORRE G, MEZZELANI A, et al. The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarooma and large deep-sealed lipoma [J] .Br j Cancer,2000, 82(7): 1271 - 1275.
  • 3DONG Y, SUI L, SUGIMOTO K, et al. Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas [J].Int J Cancer, 2001, 95 (4): 209 - 215.
  • 4SAID T K, MORAES R C, SINGH U, et al. Cyclin-dependent kinase(cdk) inhibitors / cdk4 / cdk2 complexes in early stages of mouse mammary preneoplasia [J]. Cell Growth Differ, 2001,12(6) :285 - 295.
  • 5WANG Y L, UHARA H, YAMAZAKI Y, et al. Immunohistochemical detection of CDK4 and P16INK4 protein in cutaneous malignant melanoma [J]. Bri J Dermatol, 1996,134(2): 269 - 275.
  • 6ZHANG T, NANNEY L B, LUONGO C, et al. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple inteslinal neoplasia (Min) mice and human familial adenomatous polyposis patients [J]. Cancer Res,1997,57(1 ): 169 - 175.
  • 7HE J, OLSON J J, JAMES C D. Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of edk4 is observed in distinct subsets of malignant glial tumors and cell lines [J].Cancer Res, 1995,55 (21): 4833 - 4836.
  • 8SIMON R, STRUCKMANN K, SCHRAML P, et al. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer [J]. Oncogene,2002,21 (16): 2476 -2483.

同被引文献12

  • 1白莉,余祖滨,钱桂生,李淑萍.大鼠肺动脉平滑肌细胞缺氧后STAT3活性变化与细胞增殖关系的研究[J].中国应用生理学杂志,2006,22(1):75-79. 被引量：2
  • 2[1]Huber SA,Sakkinen P,Conze D.et al.Interleukin-6 exacerbates ear-ly atherosclerosis in mice.Arterioacler Thromb Vase Biol,1999,19:2364-2367
  • 3[2]McWhinney CD,Hunt RA,Conrad KM.et al.The typel angiotensin II receptor couples to STATI and STAT3 activation through Jak2 ki-nase in neonatal rat cardiac myacytes[J].JMoll Cardiol,1997,29(9):2513-2524
  • 4[3]Watanabe S,MuW,Kahn A,et al.Role of JAK/STAT Pathway in IL-6-IndUCed Activation of Vascular Smooth Muscle Cells.Am J Nep-hrol,2004,24:387-392
  • 5Hartwell L H, Kaotan M B. Cell cycle control and cancer [J]. Science, 1994, 266(5192): 1821-1828.
  • 6Nishikawa R, Fumari F B, Lin H, et al. Loss of pl6ink4 expression is frequent in high grade gliomas [J]. Cancer Res, 1995, 55(5): 1941-1945.
  • 7He J, Olson J J, Jame C D. Lack of pl6ink4 or retinoblastoma protein(pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines [J]. Cancer Res, 1995, 55(21): 4833-4836.
  • 8Sambrook J, Fritsch E F, Maniatis T. Molecular Cloning [ M ]. 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989: 465-467.
  • 9Zhang Y, Nanney L B, Luongo C, et al. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia(Min)mice and human familial adenomatous polyposis patients [J]. Cancer Res, 1997, 57(1): 169-175.
  • 10Simon R, Struckmann K, Schraml P, et al. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GL1) in urinary bladder cancer [J]. Oncogene, 2002, 21(16): 2476-2483.

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实用医学杂志
2006年 第4期

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