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早期糖尿病肾病患者尿微量蛋白与血清MDA、TGF-β_1的相关性研究 被引量：3

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摘要 目的:探讨早期糖尿病肾病(DN)患者血清丙二醛(MDA)、转化生长因子-β1(TGF-β1)的含量与尿微量蛋白的关系。方法:分别采用定量ELISA法检测血清TGF-β1的含量,硫代巴比妥酸法检测MDA和散射速率比浊法检测尿微量蛋白的含量。结果:糖尿病(DM)患者血清MDA和TGF-β1以及MA、A1M、TRU和IgU含量明显高于正常对照组,差异有显著性意义,并对早期DN组患者血清MDA和TGF-β1水平与尿微量蛋白含量进行相关性分析(P<0.01)。结论:DM患者血清MDA和TGF-β1在DM早期即明显升高,随着DM发展至DN其水平呈递增趋势,并与尿微量蛋白含量呈正相关,表明血清中MDA和TGF-β1水平与DN的发生和发展有关。
作者 孟涛
机构地区 黄石理工学院医学院影像检验系
出处 《实用医学杂志》 CAS 2006年第4期399-400,共2页 The Journal of Practical Medicine
关键词 糖尿病肾病 转化生长因子Β 丙二醛 尿液微量蛋白
分类号 R692 [医药卫生—泌尿科学]
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  • 1林善锬.重视糖尿病肾脏病变的诊断与治疗[J].中华内分泌代谢杂志,1998,14(2):65-67. 被引量：137
  • 2Lansang MC, Hollenberg NK. Renal perfusion and the renal hemodynamic response to blocking the rennin system in diabetes.Are the forces leading to vasodilation and vasoconstriction linked.Diabetes, 2002,51: 2025-2028.
  • 3Miller JA, Curtis JR, Sochett EB. Relationship between diurnal blood pressure, renal hemodynamic function, and the renninangiotensin system in type 1 diabetes. Diabetes, 2003, 52:1806-1811.
  • 4Lane PH. Diabetic kidney disease: impact of puberty. Am J Physiol Renal Physiol, 2002,283: F589-F600.
  • 5White KE, Bilous RW, Marshall SM, et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes,2002; 51: 3083-3089.
  • 6Kveder R, Kajtna KM, Rott T, et al. Nephrotic syndrome in patients with diabetes mellitus is not always associated with diabetic nephropathy. Nephrol Dial Transplant, 2001, 16 Suppl:86-87.
  • 7Haneda M, Koya D, Isono M, et al. Overview of glucose signaling in mesangial cells in diabetic nephropathy. J Am Soc Nephrol,2003,14: 1374-1382.
  • 8Evans JL, Goldfine ID, Maddux BA, et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2diabetes. Endocrine Reviews, 2002,23: 599-622.
  • 9Limaye PV, Raghuram N, Sivakami S. Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induce diabetic rats. Mol cell biochem,2003,243:147-152.
  • 10Ziyadeh FN, Hoffman BB, Han DC, et al. Long-term prevention of renal insufficiency, excess matrix gene expressions and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-antibody in db/db diabetic mice. Proc Natl Acad Sci,2000,97:8015-8020.

共引文献373

同被引文献19

  • 1董骏武.ERK1/2途径介导苯那普利对糖尿病肾病大鼠保护作用的实验研究[J].咸宁学院学报（医学版）,2004,18(4):245-249. 被引量：1
  • 2李竞,包艳,叶迎春,秦莹,王丹,崔静.核因子-κB对糖尿病大鼠肾组织单核细胞趋化蛋白-1与细胞间黏附分子-1表达的影响[J].实用医学杂志,2007,23(5):627-629. 被引量：6
  • 3Imai G, Satoh T, Kumai T, et al, Hypertension accelerates diabetic nephropathy in Wistar fatty rats, a model of type 2 diabetes mellitus via mitogen-activated protein kinase cascades and transforming growth factor-betal [J]. Hypertens Res,2003,26(4) :339-347.
  • 4Lin C L,Wang F S,Kuo T R,et al. Ras modulation fo superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries [J]. Kidney Int, 2006,70(8) : 1523-1524,
  • 5Suzaki Y,Yoshizumi M,Kagami S,et al. BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions [J]. Kidney Int, 2004, 65(5) : 1749-1760.
  • 6Krepinsky J G, Li Y, Tang D, Stretch-induced Raf-1 activation in mesangial cells Requires actin cytoskeletal integrity [J]. Cell Signal, 2005,17(3) : 11-20.
  • 7Dlugosz J A, Mun K S, Kapor-Drezgic J, et al. Stretch-induced mesangial cell ERK1/ERK2 activation is enhanced in high glucose by decreased dephosphorylation [J].Am J Physiol Renal Physiol, 2000,279 (4) : F688 -697.
  • 8Fujita H, Omori S, Ishikura K, et al. ERK and p38 mediate highglucose-induced hypertrophy and TGF-beta expression in renal tubular cells [ J].Am J Physiol Renal Physiol,2004,286 (1): F120-126.
  • 9Nicholas S B, Aguiniga E, Ren Y, et al. Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy [J]. Kidney Int, 2005,67(4) : 1297-1307.
  • 10朱小石,李运璧.儿童过敏性紫癜早期肾上腺皮质激素治疗中尿微量蛋白的变化及意义[J].华西医学,2008,23(4):736-737. 被引量：1

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实用医学杂志
2006年 第4期

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