安康试验点精神发育迟滞遗传方式的探讨

The discussion of inheriting type of mental retardation in Ankang experimental station

目的探讨安康试验点精神发育迟滞的遗传方式,为该试验点精神发育迟滞儿童的综合防治提供依据。方法运用分离分析法和多基因阈值理论进行遗传流行病学分析。结果在安康试验点人群中,由非特异性精神发育迟滞和神经型亚克汀病所致精神发育迟滞的遗传率分别为86.61+11.10%和81.80+9.76%,最大似然法和理论子女总数法计算结果表明,不同婚配类型子女的患病率与理论患病率均无显著性差异。结论安康试验点存在两种精神发育迟滞,它们的遗传方式可能均为具有主效基因的多基因遗传。

Aim To study the modes of inheritance of mental retardation for integrate control in Ankang experimental station. Methods The genetic epidemiology methods are used to make segregation analysis and polygenic threshold model. Results In Ankang experimental station, these mental retardation population caused by non-specific mental retardation and endemic sub-clinical cretinism, have heritability of 86.61 ±11.10% and 81.80±9. 76%. The results of maximum method and theoretical children method in the two mating types have no significant difference. Conclusion In Ankang experimental station, there are two types mental retardation, and the inheritance mode is of polygenic effects and has a major gene which makes an important role.