3,5-二氯-4-吡啶酮乙酸的合成

Synthesis of 3,5-dichloro-4-pyridon-1-acetic acid

目的:以4-吡啶酮为原料,合成头孢西酮中间体3,5-二氯-4-吡啶酮乙酸。方法:4-吡啶酮与次氯酸钠迅速合成3,5-二氯-4-吡啶酮,再与一氯乙酸脱HCl制得3,5-二氯-4-吡啶酮乙酸。结果:制得3,5-二氯-4-吡啶酮乙酸。结论:该方法合成的目标产物纯度99.5%,收率89%。

Objective： To synthesize of 3, 5 - dlchloro - 4 - pyrlaon - 1 - acetic acid. Method： 3, 5-dichloro-4-pyridon was rapidly synthesized with 4-pyridon and sodium hypochlorite, and then 3,5-dichloro- 4- pyridon-1- acetic acid was prepared synthesized from 4- pyridone, ethyl ehloroaeetate reduction （-HCL）. Results ： 3,5-dichloro- 4-pyridon-1-acetic acid was synthesized. Conclusion：The synthesis method has the advantages of low cost , high yield and better product purity , suitable for industry.