老年高血压患者肾上腺髓质素及C型利钠肽的变化

Clinical investigation of plasma adrenomedullin and C-type natriuretic peptide in the elderly hypertension

目的研究老年高血压(HPE)患者血浆肾上腺髓质素(ADM)和C型利钠肽(CNP)的水平变化及其临床意义。方法放射免疫法测定136例HPE患者和40例健康老年人的血浆ADM、CNP水平,并进行对照统计分析。结果HPE组总体血浆ADM、CNP水平显著高于健康对照组(均P<0.01),HPE1、2、3级组间血浆ADM、CNP水平依次显著性递增(均P<0.01),且与高血压分级相平行(均P<0.01);HPE伴靶器官损害(TOD)组血浆ADM、CNP水平显著高于无TOD组(均P<0.01),且血浆ADM与CNP水平呈正相关(r=0.63695,P<0.01)。结论ADM、CNP可能共同参与了老年高血压的病理生理过程并在其中起代偿保护作用。

Objective To investigate the changes of plasma adrenomedullin（ADM） and C-type natriuretic peptide（CNP） levels with elderly hypertension（HPE）. Methods The plasma levels of ADM and CNP were measured by radioimmunoassay in 136 cases of the HPE（group A） compared with that of in 40 cases healthy elders （group B）. Results The plasma levelsof ADM and CNP increased significantly in group A compared with group B （P 〈 0.01 ）. The plasma levels of ADM and CNP increased significantly by degrees among Ⅰ stage, Ⅱ stage and Ⅲ stage of the HPE （ P 〈 0.01 ）. It was consistent with the hypertensive gradation （ P 〈 0.01 ）. The plasma levels of ADM and CNP increased significantly in HPE with TOD compared with HPE without TOD（ P 〈 0.01 ）. And the plasma level of ADM was positively correlated with the plasma level of CNP（ r = 0. 63695, P 〈 0.01 ）. Conclusion ADM and CNP may be involved in the pathophysiological process of the HPE and may be served as the guardian and the compensator.