妊娠期肝内胆汁淤积症孕妇肝功能指标与围生儿预后的关系

Relationship between maternal hepatic function and fetal prognosis in intrahepatic cholestasis of pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)孕妇肝功能指标与围生儿预后的关系。方法对166例ICP孕妇肝功能指标及围生儿预后进行回顾性分析。结果孕妇血清转氨酶(ALT,AST)及胆红素(BIL)水平升高者胎儿窘迫及羊水粪染发生率增加,新生儿体重及Apgar评分与胆红素水平有关,通过公式计算可以预测围生儿预后。孕妇胆汁酸(TBA)升高程度与羊水粪染及胎儿窘迫发生率无关。结论ICP孕妇转氨酶及胆红素水平升高者胎儿预后不佳,必须高度重视,适时剖宫产终止妊娠将明显改善围生儿预后。

Objective To investigate the relation between hepatic function of mothers and prognosis of fetuses in intrahepatic cholestasis of pregnancy（ICP）. Methods 166 patients with ICP were retrospectively studied, Resuits The incidences of meconium passage and fetal distress were perfectly high in mothers of high serum transaminase and bilirubin. The birth weight and Apgar scores of neonate were related to the levels of bilirubin and we could predict the fetal prognosis by analysis of mother＇s serum bilirubin level, The serum total bile acid（TBA） levels and other bepatic indexes were not related to the incidences of meconium passage and fetal distress. Conclusions The fetal prognosis of mothers with high-level serum transaminase and bilirubin is bad,so they must be taken great aware of, The prognosis of fetuses can be bettered by cesarean section at proper time.