多肿瘤标志物液态芯片技术检测恶性肿瘤的临床应用价值

Clinical value of multi-tumor markers liquid BioChip in detection to malignant tumor

目的探讨多肿瘤标志物液态芯片技术检测恶性肿瘤的临床应用价值。方法利用多肿瘤标志物液态芯片技术分析121例恶性肿瘤患者、42例良性疾病患者、39例正常对照者血清中9种常见肿瘤标志物的水平,分析该方法的灵敏度、特异性和检出肿瘤的阳性率。结果该方法对恶性肿瘤的检测有较好的灵敏度和特异性(分别为81.8%和76.5%),对肺癌、肝癌、结直肠癌、胃癌、卵巢癌、胰腺癌和前列腺癌等常见肿瘤进行9项指标联合检测的阳性率均高于单一标志物的检测(P<0.05)。结论多肿瘤标志物液态芯片定量检测是一种较好的肿瘤标志物检测方法,可以明显提高恶性肿瘤诊断的敏感性,同时也可以作为高危人群的早期肿瘤筛查手段之一,对肿瘤防治具有一定的意义。

Objective To study the Clinical value of multi-tumor markers liquid BioChip in detection to malignant tumor. Methods The 9 tumor markers were analyzed in 12lpatients with malignant tumor,42 patients with benign disease and 39 heahhy by muhi tumor markers liquid BioChip, then the sensitivity and specificity of this method were analyzed. Results The sensitivity and specificity of this method were 81. 8% and 76. 5% respectively. Moreover, the positive rate of this method in lung cancer, liver cancer, colorectal cancer, gastric cancer, ovarian cancer, pancreatic cancer and prostatic carcinoma was higher than single tumor marker detection. Conclusion The multi-tumor markers liquid bioehip technique is a better method. Combined measurement of multiple serum tumor markers using this technique can significantly increase the diagnostic sensitivity for malignant tumor, and also be used as one of earlier tumor surveying tools to asymptomatic people, especially to high risk people.