摘要
报告４７例人类白细胞抗原／混合淋巴细胞培养（ＨＬＡ／ＭＬＣ）不合的骨髓移植（ＢＭＴ）。所选病例ＨＬＡ至少有一个位点与供者不一致，或ＭＬＣ相对反应值大于１０％，或二者皆有。将患者分为胎肝与胎胸腺试用组与非试用组。非试用组患者采用常规预处理方案，试用组患者同时输注了配型不同的，胎龄为３～４个月的胎肝与胎胸腺。结果试用组患者严重的急慢性移植物抗宿主病（ＧＶＨＤ）发生率均显著低于非试用组。说明对于ＨＬＡ／ＭＬＣ不合的ＢＭＴ。
Forty-sevencasesofhumanleukocyteantigen/mixedlymphocyteculture(HLA/MLC)mismatchedalogeneicbonemarrowtsansplantation(alo-BMT)wereperformed.EachcasehadatleastoneHLAlocusmismatchand/orrelativeresponsevalueofMLChigherthan10%.Altherecipientsre-ceivedconventionalconditioningregimen,inaddition,thetrialgroup(36cases)receivedmismatched3to4month-oldfetalliver/thymuscelinfusion.Itwasfoundthatthenon-trailgroup(11cases)hadmuchmoresevereacuteandchronicgraft-versus-hostdisease(GVHD)thanthetrialgroup.Fetalliver/thymuscelinfusionseemsefectiveforpreventingGVHDinHLA/MLCmismatchedBMT.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1996年第2期73-75,共3页
Chinese Journal of Hematology
关键词
骨髓移植
移植物抗宿主病
预防
胎肝
胸腺
Bonemarrowtransplantation,alogeneicHumanleukocyteantigenGraft-versus-hostdisease
