老年动脉弹性与颈动脉粥样硬化相关性研究

Relationship between aortic flexibility and carotid atherosclerosis in the aged

目的:探讨老年人动脉弹性与动脉粥样硬化之间的关系。方法:本研究入选314例老年人,采用日本产全自动动脉硬化测定仪同步记录两侧肱动脉-踝动脉脉搏波传导速度(baPWV)作为反映大动脉弹性的指标,应用颈动脉内膜中层厚度(IMT)、颈动脉斑块的有无估计动脉粥样硬化的严重程度。结果:合并高血压患者颈动脉斑块的发生率显著高于未合并高血压组(P<0．05);baPWV在颈动脉斑块组与颈动脉无斑块组存在显著差异(P<0．001); baPWV与颈动脉IMT呈正相关(r=0.42,P<0．001);Logistic回归分析表明年龄、PWV与颈动脉斑块密切相关 (P<0．05-<0．01)。结论:动脉弹性是反应血管亚临床病变的指标,与颈动脉粥样硬化的严重程度密切相关,可作为预测颈动脉粥样硬化程度的指标之一。

Objective： To investigate the relationship between aortic flexibility and carotid atherosclerosis in the aged. Methods： A total of 314 aged men were selected. Aortic flexibility was assessed by brachial-ankle pulse wave velocity （baPWV） which was measured using an automatic device （Japan）. Carotid atherosclcrosis was assessed by common carotid intima-media thickness （IMT） and atherosclerotic plaques in the carotid artery. Results ： Patients with essential hypertension （EH） had higher incidence of atherosclerotic plaques in the carotid artery than those without EH （P〈0. 05）. BaPWV significantly increased in plaque group compared with subjects without plaques in the carotid artery （P〈0. 001） . BaPWV were found to have a strong positive association with common carotid intima-media thickness （r= 0. 42, P〈0. 001）. It was confirmed that age, baPWV were independent determinants of severity of coronary heart disease by Logistic regression analysis （P〈0. 05-〈0. 01）. Conclusion： Arterial flexibility is the parameter reflecting subclinical diseases and closely related to severity of atherosclerosis ; it ban be a marker of cardiovascular risk.