阻塞性睡眠呼吸暂停综合征与心律失常

Correlation between obstructive sleep apnea syndrome and cardiac arrhythmia

目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者病情严重程度与夜间心律失常的关系,以及经鼻持续气道内正压(nCPAP)通气治疗对心律失常的影响。方法:183例OSAS患者按睡眠呼吸暂停／低通气指数(AHI)分轻、中、重三组,观察夜间最低血氧饱和度,窦停,Ⅱ、Ⅲ度房室传导阻滞,室早总数、心律失常总数及发生率,比较组间差异性,并对130例患者进行了nCPAP治疗前后上述各项参数的比较。结果:OSAS夜间心律失常随病情程度加重而明显加重。轻度、中度、重度患者组间两两比较上述各项参数有显著差异(P均<0．05);nCPAP治疗7 h 后心律失常均明显改善(P<0．05)。心律失常的发生总数与SaO2最低值呈负相关(r=-0．51,P<0．01)。结论:夜间心律失常随OSAS病情加重而明显加重,nCPAP治疗能明显减轻夜间心律失常。

Objective： The aim was to study the relationship between the degree of obstructive sleep apnea syndrome （OSAS） and arrhythmia in night; the effect of nasal continuous positive airway pressure （nCPAP） on cardiac arrhythmia. Methods： A total of 183 OSAS patients were selected and their Hoher monitoring in sleep were performed. The minimum SaO2 and parameters of arrhythmia were observed. The 130 OSAS patients accepted the therapy of nCPAP and were followed-up. Results： The arrhythmia increased in night companied with the serious degree of OSAS. There were significant difference （P〈0.05） in arrhythmia among mild group and intermediate group;intermediate group and serious group. After nCPAP therapy 7 h,arrhythmia improved in all groups （P〈0.05）. There was negative correlation between the total number of arrhythmia and SaO2min（r=-0.51, P〈0.01）. Conclusion： With the increase of the severity of OSAS, the arrhythmia is more serious; the therapy of nCPAP can improve the arrhythmia in night.