淫羊藿总黄酮注射液对正常麻醉开胸犬血流动力学的影响

Effects of Total Flavonoids of Epimedium on Hemodynamics in the Anaesthetized Chest-open Dogs

目的观察淫羊藿总黄酮注射液对正常麻醉开胸犬血流动力学的影响。方法用脉冲多普勒超声血流仪分别测定心输出量、血压和冠脉流量,心导管插管测定左室内压,BIOPAC多导生理仪记录心电图。结果淫羊藿总黄酮注射液可减慢心率,升高收缩压,短暂降低舒张压,增加心输出量、冠脉流量、心脏指数、左室做功指数,降低总外周阻力、冠脉阻力和左室内压最大变化速率,降低心肌耗氧指数,对左室内压无明显影响。结论淫羊藿总黄酮注射液可通过增加冠脉流量,增加氧的供应,降低心肌耗氧量,改善心脏血流动力学。

Aim To observe the effects of total flavonoids of epimedium （TFE） injection on hemodynamics and myocardial oxygen consumption index in the normally anaesthetized chest-open dogs. Methods The parameters of hemodynamics such as cardiac output （CO）, blood pressure, coronary blood flow and the left ventricular pressure（LVP） through cardiac catheterization were determined by pulsed wave Doppler ultrasonic flowineter; the electrocardiogram was measured by BIOPAC polygraphy. Results After the dogs were administrated with the TFE, the heart rate （HR） slowed down, and the systolic blood pressure （SBP） ascended, but the diastolic blood pressure （DBP） declined transiently. The coronary blood flow （CBF） increased while the coronary vascular resistance （CVR） decreased significantly. Although LVP was not changed by TFE, the maximum rise rate and the maximum decline rate of the left ventficular pressure （ ± dp/dtmax） were decreased obviously, whereas the cardiac index（CI） and left ventricular work index（LVWI） were increased. In addition, CO was increased remarkably. Meanwhile the total periphery resistance （TPR） and the myocardial oxygen consumption index were reduced. Conclusion TFE can improve the heart function by increasing the coronary blood flow and decreasing the myocardial oxygen consumption.