胃癌根治术中腹腔低渗热灌注化疗的临床研究

Clinical Study of Hypotonic Intraoperative Intraperitoneal Chemohyperthermia for Gastric Cancer

目的探讨术中腹腔低渗温热灌注化疗对胃癌患者术后的临床疗效。方法将术中行一次性腹腔低渗温热灌注化疗的37例胃癌患者(灌注化疗组)与未行此方法的31例患者(对照组)的复发及预后情况进行比较。结果手术并发症2组间无显著性差异。灌注化疗组的术后复发率(18.91%)显著低于对照组(51.61%),复发时间亦显著晚于对照组,差异有显著性(P<0.01)。灌注化疗组1,3,5年生存率分别为8 8.5 6%,7 6.8 5%和5 2.3 1%,而对照组则分别为8 0.2 1%,5 7.9 2%和2 1.2 2%,两组比较3,5年生存率有显著差异(P<0.0 5)。结论一次性术中腹腔内低渗温热灌注化疗可降低患者术后复发率和提高生存率,操作简便、高效、安全。

Objectlve To investigate the clinical effect and value of hypotonic intraoperativeintraPeritoneal chemohyperthermia （HIPCH） in advanced gastric cancer. Methods Thtriy-seven cases received HIPCH and other thirty - one cases in control group received onlysaline water lavage after radical resection. Results No difference was found in thecomplimentary rate between the two groups （ P 〉 0.05 ）. The interval before tumor recurrence wassignifieantly longer in HIPCH group than those of the control group. The 1-,3-,5-year survivalrates were 88.56% 76.85 % and 52.31%, and 80.21% 57.92% and 21.22% respectivdy jn thetreatment and control groups. There were significam differences in the 3-,5-year survivai ratesbetween two groups （ P 〈 0.05 ）. conclusion HIPCH can kill isolated intraperitoneal cancercells, reduce peritoneal recurrence after radical resection and improve the prognosis. It is a kind ofconveninent, highly effective, and safe treatment method for advanced gastric cancer.