高压氧对新生儿缺氧缺血性脑病的预后影响

The Influence of Hyperbaric Oxygen on the Prognosis of Neonates with Hypoxic-ischemic Encephalopathy

目的探讨高压氧(HBO)对缺氧缺血性脑病(H IE)的远期疗效。方法将90例符合H IE诊断标准的足月新生儿分为两组。治疗组50例,对照组40例。对照组仅给予常规治疗,治疗组在常规治疗的基础上加用HBO。结果治疗10 d后治疗组患儿的脑电图异常率,特别是重度异常率明显低于对照组(χ2=8.2,P<0.05);治疗1个月后治疗组头颅CT异常明显低于对照组(χ2=7.89,P<0.05);治疗3个月后治疗组DQ明显优于对照组(χ2=10.98,P<0.05)。结论高压氧对足月新生儿缺氧缺血性脑病的治疗作用明显,疗效肯定。

Objective To explore the curative effect of hyperbaric oxygen to neonates with hypoxic-ischemic encephalopathy at a specified future date. Methods Ninety mature neonates with hypoxic - ischemic eneephalopathy were divided into two groups, expcrimertal group （n =50） treated with common treatment and hyperbaric oxygen and common group （n = 40） only treated with common treatment. Results Not only the ratios of abnormality recorded by electroencephalogram and CT were obviously lower in experimentat group than in common group after some days＇treatment （X^2 = 8.2, P 〈 0.05; X^2 = 7.89, P 〈 0.05）, but discipline quotient was better than that of common group as well （X^2 = 10.98, P 〈 0.05）. Conclusion The treatment effect of hyperbaric oxygen on newborns with hypoxic-ischemic encephalopathy is very remarkable.