肝硬化患者血浆凝血因子的分析

Plasma Coagulation Factors in Patients With Cirrhosis

目的系列检测60例肝硬化患者血浆凝血因子,并与同期正常对照进行比较,探索其临床意义。方法凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)均采用凝固比浊法测定,血小板(PLT)用美国AB-BOTT CELL-DYNl600型全自动血球计数仪检测。凝血因子活性测定采取一期凝血法。结果肝硬化组PT、APTT较对照组明显延长(P<0.05),FIB、PLT较对照组显著减低(P<0.05)。凝血因子Ⅷ的活性较对照组明显增高(P<0.05),而凝血因子Ⅱ、Ⅴ、Ⅶ、Ⅸ、Ⅺ、Ⅻ的活性较对照组显著降低(P<0.05)。结论肝硬化患者血浆凝血因子异常是加重其疾病发展的重要原因之一,早期肝硬化进行凝血因子检测,有助于早期发现肝病时造成的凝血障碍,有助于判定病情预后,对肝硬化出血的抢救和治疗,具有重要的临床意义。

Objective The plasma coagulation factors were evaluated in 60 patients with liver cirrhosis. Methods The blood prothrombin time（PT）, activated partial thromboplastin time （APTT） and plasma fibrinogen level （FIB） were determined by coagulant turbidity method. Blood platelet count （PLT） was measured with ABBOTT CELL - DYN1600 automatic blood cell counter. The activities of coagulation factors were detected by one clotting stage method. Results The PT and APTT in patients with cirrhosis were significantly prolonged than that of normal controls as well as the decrement of FIB leveland PLT count （P〈 0.0.5）. The activity of factor Ⅶ was elevated, tn contrast, the activities of other coagulation factors, such as FⅡ ,FⅤ ,FⅦ ,FⅨ,FⅪFⅫwere decreased （P〈0.05）. Conclusion The PT and APTT interval, the levels of FIB and PLT count and all other coagulation factors are abnormal in patients w th hepatic cirrhosis, they are valuable in identifying coagulation disorders characterizing the degree of liver damage, predicting bleeding tendency and estimating prognosis.