摘要
目的探讨肿瘤相关抗原表达对胆囊癌早期诊断及其预后判断的价值。方法采用免疫组化染色对50例胆囊癌、10例胆囊腺瘤、10例慢性胆囊炎的增生细胞核抗原(PCNA),癌胚抗原(CEA),癌相关黏液抗原(CA50)和钙黏蛋白E(E-cad)表达进行检测。结果胆囊癌CEA,CA50阳性表达率显著高于腺瘤和胆囊炎组(P<0.05);而E-cad阳性表达率明显降低,伴有转移者E-cad表达更低。胆囊癌PCNA标记指数(LI)高于胆囊炎和腺瘤组(P<0.01)。CEA,PCNA过度表达者其3年生存率显著降低(P<0.01),E-cad过度表达者其3年生存率较阴性组明显增高(P<0.05)。结论PCNA,CEA及CA50检测可能有助于胆囊腺瘤癌变和胆囊癌的早期诊断,且PCNA,CEA和E-cad检测可作为胆囊癌预后判断的参考指标。
Objective To study the value of expression of carcinoma-associated antigens in early diagnosis and prediction of prognosis of gallbladder carcinoma. Methods The expression of PCNA, CEA, CA50 and E-cad were detected by immunohistochemistry in 50 cases of gallbladder carcinoma, l0 gallbladder adenomas and l0 cholecystitis. Results The positive rates of CEA, CA50 and PCNA LI in gallbladder carcinomas were significantly higher than that of gallbladder adenomas and cholecystitis（P 〈0.05）. The positive rate of E-cad in gallbladder carcinomas was significantly lower than that of gallbladder adenomas and cholecystitis （P 〈0.05）. 3-year-survival rate was significantly lower in gallbladder carcinomas with CEA and PCNA overexpression （P 〈0.05）, and 3-year-survival rate in the patients with E-cad positive tumors was higher than that of those with E-cad negative tumors （P 〈0.05）. Conclusion The detection of CEA, CA50 and PCNA is useful for early diagnosis of gallbladder carcinomas and malignant change in gallbladder adenomas. Therefore, CEA, PCNA and E-cad may be valuable in predicting prognosis of gallbladder carcinomas.
出处
《肿瘤研究与临床》
CAS
2006年第2期102-103,105,共3页
Cancer Research and Clinic
