急性白血病患者血清白细胞介素-3及转化生长因子-β_1水平检测的临床意义

Clinical significance of interleukin-3, TGF-β_1 levels in serum of patients with acute leukemia

目的探讨白细胞介素-3(IL-3)、转化生长因子-β1(TGF-β1)在急性白血病(AL)中的临床意义。方法采用酶联免疫试验(ELISA)动态检测83例AL患者化疗前、完全缓解期以及长期缓解期等不同时间段血清IL-3,TGF-β1水平。结果AL初诊患者血清IL-3,TGF-β1水平明显低于正常对照组(P<0.05),完全缓解期IL-3,TGF-β1水平恢复正常;未缓解和复发患者IL-3,TGF-β1水平与初诊患者差异无统计学意义(P>0.05)。直线相关分析表明,IL-3水平与TGF-β1呈正相关(r=0.817,P<0.05)。长期缓解的患者IL-3,TGF-β1水平维持正常。结论检测IL-3,TGF-β1水平变化有助于AL病情观察,作为疗效观察的辅助指标。

Objective To investigate the prognostic significance of interleukin-3（IL-3）, transforming growth factor-β1（TGF-β1）levels in patients with acute leukemia （AL）. Methods ELISA assay were employed to investigate the levels of IL-3, TGF-β1 before treatment and in complete remission period and long term remission period in 83 AL patients. Results The levels of IL-3 and TGF-β1 were much lower at the time of diagnosis than that of controls （P 〈0.05）. The levels returned to normal levels in those who got complete remission （CR）. There was no difference among non-remission（NR）, relapsed and preliminary diagnosis patients. Line correlation analysis： IL-3 correlated positive with TGF-β1,（r =0.817, P 〈0.05）. The levels of IL-3 and TGF-β1, of CR for a long time group remained normal. Conclusion Monitoring the levels of IL-3 and TGF-β1, may have prognostic value in clinical outcome and are useful markers of curative effect in AL patients.