移植后树突状细胞、亚群重建规律及其与急性移植物抗宿主病的关系

Reconstitution dynamics of dendritic cells and subset after allogeneic hematopoietic stem cell transplantation and its relation with aGVHD

异基因干细胞移植后树突状细胞(DC)恢复的特点是移植后DC细胞亚群均较移植前水平降低,单核细胞样DC在移植后300￣400d可以恢复正常水平,浆细胞样DC恢复很慢。它的重建受到粒细胞刺激因子、前炎性的细胞因子的影响,与异基因移植CD3+4细胞剂量无关。通过分析DC与移植物抗宿主病(GVHD)关系的分析,发现低数量的DC会导致GVHD的高发生率,并有学者对这种现象的机制进行了解释。就移植后树突状细胞、亚群重建规律及其与急性移植物抗宿主病的关系进行综述。

Patients dendritic cells recovery after allogeneic hematopoietic stem cell transplantation （allo-HSCT） is characterized by low dendritic ceils subset after transplantation comparision with before transplantation. The second charactisitic is that monocyte-derived DCs may recover normal in 300-400 day after transplantation, plasmacytoid DCs slowly recover is the other one. Patients dendritic cells reconstitution after allo-HSCT is affected by granulocyte colony-stimulating factor, proinflammatory cytokine secretion and mesenchymal stem cells,and regardless of donor CD34（＋） dose. By analysis of dendritic ceils and acute graft-versus-host disease （aGVHD）, it is aquired that low dendritic cell count after allogeneic hematopoletic stem cell transplantation predicts high incidence rate of GVHD, and some scholars explained the system of this phenomena. This chapter is reviewed with reconstitution dynamics of dendritic cells and subset after allogeneic hematopoietic stem cell transplantation and its relation with aGVHD.