微流控芯片二维电泳分离分析系统研究进展

Two-dimensional electrophoresis on microfluidic chip

微流控芯片分析系统(微全分析系统)近年来发展迅速,已经被应用于生物、环境样品的分离分析研究。多维分析系统能够极大地提高峰容量,适合于复杂样品体系的分离分析。在微流控芯片上进行的分离操作不仅可以有效地实现两种分离模式之间的零死体积切换,而且能够使分析速度与峰容量的矛盾得到补偿。本文对微流控芯片二维电泳分离分析系统的近期发展作综述,并展望其可能的发展前景。

Microfabricated, microfluidic devices constructed on planar substrates have been shown to be highly advantageous for manipulating small sample volumes, rapidly processing materials, and integrating sample pretreatment and separation strategies. The advantage of multidimensional techniques is that high peak capacities can be achieved. In this paper we briefly outline the development of two-dimensioaal separation system on microfabricated device in recrnt years.