基因治疗与心脏起搏
摘要
随着基因治疗的突飞猛进,在动物实验模型上利用基因工程技术转染β肾上腺素受体的互补DNA、K ir2.1(转运编码内向整流电流IK1,一个α亚单位基因)基因、HCN2(超极化激活的环核苷酸门控2)基因等创造的生物起搏器在不久的将来,基因治疗心脏起搏功能障碍将会成为可能。
出处
《中国心脏起搏与心电生理杂志》
2006年第1期79-81,共3页
Chinese Journal of Cardiac Pacing and Electrophysiology
参考文献19
-
1Da Costa A,Kirkoriall G,Cucherat M,et al.Antibiotic prophylaxis for permanent pacemaker implantation:A meta-analysis[J].Circulation,l998,97:1 796
-
2Barold SS,Zipes DP.Cardiac pacemakers and antiarrhythmic devices[J].Heat,Disease,1997,44:705
-
3任晓庆,浦介麟,张澍,贾玉和,吴国玫,孟亮,王方正.自体骨髓间叶干细胞诱导分化移植治疗房室阻滞的初步观察[J].中国心脏起搏与心电生理杂志,2005,19(1):48-52. 被引量：17
-
4Izhak K,Kenyagin-Karsenti D.Human embryonic stem cells can differentiate into myocytes with shuctural and functional propeHies of cardiomyocytes[J].Ciro Res,2002,89:109
-
5Holmer SR,Homey CJ.c proteins in the heaH.A redundant and diverse transmembralte signaling network[J].Circulation,199,84:1 891
-
6Inglese J,Freedman NJ,Koch WJ,et al.Structure and mechanism of the G pmtein-coupled receptor kinases[J].J Biol Chem,1993,268:23 735
-
7Lefkowitz RJ,Caron MG.Adrenergic receptors.Models for the study of receptors coupled to guanine nucleotide regulatory proteins[J].J Biol Chem,1998,263:4 993
-
8Edelberg JM,Aird WC,Rosenberg RD.Enhancement of murine cardiac chronotropy by the molecular transfer of the human[beta]2 aderenergic receptor Cdna[J].J Clin Invest,1998,101:337
-
9Edelberg JM,Huang DT,Josephson ME,et al.Molecular enhancement of porcine cardiac chronotropy[J].Heart,2001,86:559
-
10Keating MT,Sanguineni MC.Molecular and cellular mechanisms of cardiac arrhythmias[J].Cell,2001,104:569
二级参考文献12
-
1Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284: 143.
-
2Fukuda K. Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes[J]. Bone Marrow Transplant, 2003, 32(suppl 1): S25.
-
3Orlic D. Adult bone marrow stem cells regenerate myocardium in ischemia heart disease[J]. Ann N Y Acad Sci, 2003, 996: 152.
-
4Tomita S, Mickle DA, Weisel RD, et al. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation[J]. J Thorac Cardiovasc Surg, 2002, 123: 1 132.
-
5Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro[J]. J Clin Invest, 1999, 103: 697.
-
6Fukuda K. Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering[J]. Artif Organs, 2001, 25(3): 187.
-
7Gojo S, Gojo N, Takeda Y, et al. In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells[J]. Exp Cell Res, 2003, 288(1): 51.
-
8Korbling M, Estrov Z. Adult stem cells for tissue repair - a new therapeutic concept[J]? N Engl J Med, 2003, 349: 570.
-
9Chiu RC. Bone-marrow stem cells as a source for cell therapy[J]. Heart Fail Rev, 2003, 8(3): 247.
-
10Henon PR. Human embryonic or adult stem cells: an overview on ethics and perspectives for tissue engineering[J]. Adv Exp Med Biol, 2003, 534: 27.
共引文献16
-
1蔡军,林国生,江洪,杨波,蒋学俊,王腾,范国华,余奇劲.同种异体心肌细胞移植治疗缓慢性心律失常的实验研究[J].中国心脏起搏与心电生理杂志,2005,19(4):280-283. 被引量：7
-
2浦介麟,向晋涛,蒋文平.加强对遗传性心律失常的认识和研究[J].中国心脏起搏与心电生理杂志,2006,20(1):1-3. 被引量：4
-
3马克娟,浦介麟.遗传性心律失常基因研究近况[J].中国心脏起搏与心电生理杂志,2006,20(1):4-7. 被引量：6
-
4黄浙勇,葛均波.干细胞移植治疗心律失常的研究进展[J].中国临床医学,2007,14(2):151-154. 被引量：4
-
5付翠平,伍伟锋.成体干细胞及其在心脏疾病中的应用[J].医学综述,2007,13(10):763-765. 被引量：1
-
6吴美华,陈章强,李华泰.缓慢性心律失常生物心脏起搏治疗的研究进展[J].中国心脏起搏与心电生理杂志,2007,21(3):263-265. 被引量：2
-
7张喜,张传森.超极化激活的环核苷酸门控的离子通道与生物心脏起搏器构建[J].中国心脏起搏与心电生理杂志,2007,21(6):535-537.
-
8冯川,田杰,杜军保.心律失常的干细胞治疗现状[J].实用儿科临床杂志,2008,23(1):16-18.
-
9葛均波,黄浙勇.干细胞移植治疗心律失常的实验研究和展望[J].中华心律失常学杂志,2008,12(3):227-229.
-
10管思彬,马爱群,蒋文慧.细胞治疗在生物起搏中的研究进展[J].中国心血管病研究,2008,6(10):797-799.
-
1李运有,张寄南,王敬良.β肾上腺素受体及其基因的结构与功能调节研究进展[J].国外医学（分子生物学分册）,1990,12(5):232-235.
-
2李艳芳,张利,郑秋甫.心脏血管紧张素Ⅱ受体与β肾上腺素受体相关的调节特点[J].中国循环杂志,1999,14(4):252-253. 被引量：2
-
3杨慧芳.豚鼠心肌细胞中Kir2.1对内向整流钾电流组成的贡献[J].河北医药,2011,33(13):1943-1944. 被引量：4
-
4刘凡,刘坤申.生物起搏器与基因疗法[J].心血管病学进展,2004,25(B12):97-99. 被引量：3
-
5单迎光,黄从新.TBX18及其相关转录因子与生物起搏[J].中国心脏起搏与心电生理杂志,2017,31(1):65-68.
-
6刘亚平.β肾上腺素受体与左旋精氨酸/一氧化氮通路[J].心血管病学进展,2002,23(1):49-51.
-
7权大君,黄鹤,曹政.生物起搏器的研究进展[J].中国心脏起搏与心电生理杂志,2016,30(6):547-550.
-
8尹元琴,隋承光,陈红,任常山.人神经生长因子cDNA的体外扩增和序列测定[J].中国医科大学学报,2001,30(6):404-405. 被引量：1
-
9Rosen MR.,王如兴（节译）,李肖蓉（节译）,蒋文平（校）.生物起搏器:一个已经到来还是即将来临的概念[J].心血管病学进展,2007,28(3):502-503.
-
10李艳芳,张幼恰,易永梅,韩启德.心脏β肾上腺素受体及其亚型随年龄而变化[J].生理学报,1997,49(3):281-284. 被引量：11
