1524例先天性唇腭裂的临床分类和发病因素分析

Clinical classification and etiological study in 1524 patients with congenital cleft lip and cleft palate

作者统计１５２４例先天性唇腭裂患者中，唇裂合并腭裂。唇裂或伴牙槽裂，单纯腭裂，分别占６０．８３％，２６．５１％，１２．６６％。男女比为１．８９：１。本资料显示，多基因遗传是唇腭裂的重要病因之一。胚胎早期的外环境包括感染，药物，毒物，放射线，妊娠呕吐，精神因素，全身疾病和多胎生育与唇腭裂发生有关。以综合征出现的唇腭裂应考虑单基因突变。

Abstract A total of 1524 patients with cleft lip and cleft palate was classified to cleft lip with palate,cleft lip with or without alveolus cleft,and cleft palate,accounting for 60.83%,26.51% and 12.66% respectively.The data showed that nultigenic inheritance was one of the most important factors in the development of cleft lip and cleft palate.The embryonic enviromental factors including infection,drug intaking,poisoning,trauma,radiation,morning sickness, psychogenic factors,systemic diseases and multifelation were relative to cleft lip and cleft palate induced. The syndrome associated with cleft lip and cleft palate might be considered as a single gene aberration.