酸枣仁中的一种新羽扇豆烷型三萜(英文)

A novel lupane triterpene from seeds of Ziziphus jujuba var.spinosa

目的研究酸枣仁Z iz iphus jujuba var.sp inosa的化学成分。方法利用硅胶柱色谱进行分离纯化,通过理化方法及光谱分析鉴定其结构。结果从酸枣仁乙醇提取液中得到6个化合物,分别鉴定为2,α3-βd ihydroxy-lup-20(29)-en-28-oc i ac id m ethy l ester(Ⅰ)、β-谷甾醇(Ⅱ)、白桦酯醇(Ⅲ)、白桦酯酸(Ⅳ)、1-十六烷酸甘油酯(Ⅴ)、胡萝卜苷(Ⅵ)。结论化合物Ⅰ为新化合物,命名为罗珠子酸甲酯(a lph ito lic ac id m ethy l ester),化合物Ⅴ为首次从酸枣仁中分离得到。

Objective To study the chemical constituents from the seeds of Ziziphus jujuba var. spinosa, which is used as a sedative herbal medicine in China. Methods The constituents were separated and purified by silica gel column. Their structures were elucidated based on their physicochemical properties and spectral analysis. Results Six compounds were obtained from 95% EtOH extracts in the seeds of Z. jujuba vat. spinosa. They were identified as 2α, 3βdihydroxy-lup-20（29）-en-28-oic acid methyl ester （Ⅰ）, βsitosterol （Ⅱ）, betulin （Ⅲ）, betulinic acid （Ⅳ）, hexadexanoic acid 2, 3-dihydroxypropyl ester （Ⅴ）, and daucosterol （Ⅵ）. Conclusion Compound Ⅰ is a novel lupane triterpene named as alphitolic acid methyl ester, compound Ⅴis obtained from the seeds of Z. jujuba var. spinosa for the first time.