冠心病介入治疗术前、后血浆内皮素-1水平变化的研究

A Study on the Level Change of Plasma Endothelin-1 in Preprocedural and Postprocedural Coronary Interventions

目的研究冠心病患者介入治疗术前、后血浆内皮素-1(ET-1)水平的变化。方法60例冠心病患者行经皮腔内冠状动脉成形术及即刻支架置入术(PTCA&S),分别于PTCA前,PTCA后5 m in,支架置入后即刻(0m in)、5 m in和10 m in采集外周静脉血,于术后12 h,1 d,3 d,7 d继续采集外周血,测试ET-1水平。结果PTCA术前、术后5 m in、支架置入后即刻(0 m in)、5 m in、10 m in和术后12 h、1 d、3 d、7 d患者血浆ET-1均值间差别有显著性意义(P<0.05);ET-1水平在支架置入后即刻和术后12 h呈大小2个高峰(P<0.05或<0.01)。结论PTCA&S术后ET-1呈2次释放高峰,可能与术后血管痉挛、血栓形成和心肌顿抑等有密切关系。

Objective To study the level change of endothelin - 1 （ ET - 1 ） in preprocedural and postprocedural coronary interventions. Methods 60 patients with coronary artery disease underwent percutaneous transluminal coronary angioplasty and immediate sent implantation （PTCA＆S）. ET - 1 levels were measured before PTCA, immediately and 5 min, 10 min after the implantation. The peripheral vein blood was taked at 12 h, 1 d, 3 d and 7 d after the implantation. Results The level of ET - 1 exhibited two peaks which is immediately and 12 h after the implantation （ P 〈 0. 05, P 〈 0. 01 ）. Conclusion The level of ET - 1 exhibited two peaks after the sent implantation, which might have close relation with the vasospasm and myocardial stunning.