甜菜碱的生物活性研究

Study on bioactivities of betaine

介绍了甜菜碱的生物活性,包括调节体内渗透压,增加细胞Na/K-ATP酶的活性;促进脂肪代谢,抑制脂肪肝,其机制是甜菜碱能显著促进体内腺苷甲硫氨酸(SAM)的合成,降低肝脏中胆固醇和甘油三酯的含量;应用受体的放射配基结合分析法测定出甜菜碱对大鼠肝细胞膜表皮生长因子受体(EGF)及其酪氨酸蛋白激酶(TPK)有显著的结合抑制作用.

This paper mainly introduces some bioactivities of betaine, it can regulate the osmotic stress. Increase the activity of Na/K - ATPase; it also can enhance the metabolism of fat, inhibit the steatosis, the mechanism is that the betaine can increase the synthesis of SAM, decrease the triglycerides and cholesterol. Using radioligand of binding assay of receptors determinates that betaine can inhibit the binding of EGF receptor with EGF and affect the TPK activity conspicuously.