全身照射在异基因骨髓移植治疗白血病中的应用

Theapplicationoftotalbodyirradiationtoalogeneicbonemarrowtransplantationforthetreatmentofleukemia

分析了６５例异基因骨髓移植治疗白血病时两种全身照射（ＴＢＩ）剂量与早期毒性反应、早期死亡、白血病复发及生存率、急性移植物抗宿主病及间质性肺炎的关系。９．９Ｇｙ组有３５例，１２．０Ｇｙ组有３０例。两组的早期毒性反应及早期死亡无差别。移植后１２Ｇｙ组的无病生存率稍高于９．９Ｇｙ组。１２Ｇｙ组的白血病复发率低（Ｐ＜０．０５）。急性移植物抗宿主病发生率高（Ｐ＜０．０５）。间质性肺炎的发生两组无差别。异基因骨髓移植中ＴＢＩ１２Ｇｙ组的疗效好于９．

Sixty-fiveleukemiapatientsweretreatedwithalogeneicbonemarrowtransplantation.Twodiferentdosagesweredeliveredtothepatientsintotalbodyirradiation(TBI).Therewerenodif-ferencesinearlytoxicity,earlydeathandtheincidenceofinterstitialpneumoniabetweenthe12Gy(n=30)and9.9Gy(n=35)groups.Bycomparison,thediseasefreesurvivalratewasmuchhigher,there-lapseratewasmuchlower(P<0.05)andtheincidenceofacutegraft-versus-hostdisease(GVHD)and>grade2GVHDweremuchhigher(P<0.05)in12Gygroupthanthosein9.9Gygroup.