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肾细胞癌(综述) 被引量:1

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摘要 在美国,肾癌发病率在男性恶性肿瘤中占第7位,在女性中占第12位,占全部癌症的2.6%。大约2%的肾癌病例与遗传综合征有关。在美国,预计2005年有36160例肾癌新发病例,由于广泛普及了放射影像学检查,许多病例能够早期被发现。但是,预计2005年仍有12660例病人死于这种疾病。肾细胞癌起源于肾上皮细胞,约占肾癌的85%。四分之一的病例就诊时已属于晚期,包括局部侵袭性或转移性肾细胞癌。另外,三分之一接受了局部病灶切除的病人会出现复发。发生癌转移者的中位生存期大约是13个月。因此,迫切需要更有效的手术和药物疗法。
出处 《中国农村医学杂志》 2006年第2期70-75,共6页 Chinese Journal of Rural Medicine
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  • 1葛涛,范鸣.抗癌药Sorafenib[J].药学进展,2005,29(7):338-338. 被引量:2
  • 2WILHELM SM,CARTER C,TANQ L,et al.BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis[J].Cancer Res,2004,64(19):7099-7109.
  • 3WILHELM S,CHIEN DS.BAY 43-9006:preclinical data[J].Curr Pharm Des,2002,8(25):2255-2257.
  • 4STRUMBERG D,VOLIOTIS D,MOELLER JG,et al.Results of phase Ⅰ pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors[J].Int J Clin Pharmacol Ther,2002,40(12):580-581.
  • 5LATHIA C,LETTIERI J,CIHON F,et al.Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics[J].Cancer Chemother Pharmacol,2006,57(5):685-692.
  • 6KUPSCH P,HENNING BF,PASSARGE K,et al.Results of a phase Ⅰ trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors,including colorectal cancer[J].Clin Colorectal Cancer,2005,5(3):188-196.
  • 7RICHLY H,HENNING BF,KUPSCH P,et al.Results of a Phase Ⅰ trial of sorafenib (BAY 43-9006)in combination with doxorubicin in patients with refractory solid tumors[J].Ann Oncol,2006,17(5):866-873.
  • 8RICHLY H,KUPSCH P,PASSAGE K,et al.A phase Ⅰ clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI)BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors[J].Int J Clin Pharmacol Ther,2003,41 (12):620-621.
  • 9MROSS K,STEINBILD S,BAAS F,et al.Drug-drug interaction pharmacokinetic study with the Raf kinase inhibitor (RKI)BAY 43-9006 administered in combination with irinotecan (CPT-11)in patients with solid tumors[J].Int J Clin Pharmacol Ther,2003,41 (12):618-619.
  • 10RATAIN MJ,EISEN T,STADLER WM,et al.Phase Ⅱ placebocontrolled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma[J].J Clin Oncol,2006,24(16):2505-2512.

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