摘要
目的了解甲基叔丁基醚(MIBE)对中枢神经系统的作用部位,为进一步探讨MTBE对中枢神经系统的急性毒作用机制。方法雄性SD大鼠腹腔注射MIBE(0.075mL/50g)染毒1h后,应用免疫组织化学、显微图像分析技术检测Fos蛋白阳性神经元在中枢神经系统内的分布。结果7MTBE染毒组大鼠大脑皮质、下丘脑、小脑皮质均有Fos阳性神经元核团表达。结论MTBE对中枢神经系统具有明确的毒作用位点。
Objective To undetstand the distribution of C - los oncogene expression induced by MTBE in central nervous system technique (ABC method) was employed to detect C - fos oncogene. Results When toxic dose of MTBE was 0.075 ml/50g, four Fos part appeared in the central nervous system, including cerebral cortex, hypothalamus, cerebellar cortex. Condusion MTBE has the determined sites of action in central nervous system.
出处
《美国中华临床医学杂志》
2006年第1期60-62,共3页
American Journal of Chinese Clinical Medicine
基金
湖南省卫生厅资助项目(No.B2005090)